Abstract: The invention provides a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Oligonucleotide microarrays were used to analyze mRNA expression levels corresponding to 12,600 transcript sequences in 186 lung tumor samples, including 139 adenocarcinomas resected from the lung. Hierarchical and probabilistic clustering of expression data defined distinct subclasses of lung adenocarcinoma. Among these were tumors with high relative expression of neuroendocrine genes and of type II pneumocyte genes, respectively. Retrospective analysis revealed a less favorable outcome for the adenocarcinomas with neuroendocrine gene expression. The diagnostic potential of expression profiling is emphasized by its ability to discriminate primary lung adenocarcinomas from metastases of extrapulmonary origin. These results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients.

Abstract: This nonprovisonal utility patent application is for a new type of backyard composter The composter is “convertible” and converts from a “closed” unit (with two black panels in place to an “open” unit (with two panels removed, and the screens revealed). The screens allow only fully decomposed matter to filter out, when the bin is rotated. The scope of protection offered by the patent should prevent the manufacture of a residential rotating composting device with removable panels with screens behind them.

Abstract: A neural network system and method for analyzing data sets, especially microarray gene expression data. The neural network is trained to generate time-dependent outcome predictions based on input features and outcome functions for a number of subjects. The features may be highly dimensional relative to the number of subjects, and feature selection is applied to the input feature data for training the neural network. A trained neural network processes input features from a subject to generate an outcome function that reflects the probability of the occurrence of an event at a given time point for that subject.

Abstract: Disclosed are polynucleotide and polypeptide sequences involved in or associated with isoprenoid biosynthesis in plants. Also disclosed are uses for such sequences.

Abstract: An appliance, such as a refrigerator, is provided with a door handle with colored caps for covering the door handle fasteners. The caps are exchangeable with other caps having different colors, as chosen by the consumer. The refrigerator also includes storage buckets, shelves and drawers with colored trim pieces which are exchangeable with different colored trim pieces, as well as a water dispenser having a colored actuation button and a colored sump tray, both of which can be exchanged with different colored buttons and trays.

Abstract: The present invention provides novel solution phase hybridization-based methods for detecting and quantitating nucleic acid analytes. Methods comprising use of novel capture polymers and/or signaling systems are provided. Use of these novel capture polymers and/or signaling systems provides significant improvements in signal to noise ratio, specificity, sensitivity and ease of development and use as compared to existing solution phase nucleic acid detection and quantitation methods. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.

Abstract: Devices and processes (e.g., improved Plasticized Melt Flow processes (PMF) or improved Phase Separation Polymer Concentration (PSPC), etc.) used to make resorbable and non-resorbable structures for treating and/or healing of tissue defects are disclosed. Among the advantages of using these improved processes are the preservation of molecular weight and the broadening of the processing conditions for temperature sensitive polymers and therapies This reduction in processing temperature, pressure and time can help to preserve the molecular weight and/or integrity of the final product or any additive incorporated therein. The present invention relates to an improved porous implant wherein the pores of the implant present a second modeling material on their surfaces. This second material provides a textured or roughened face to the internal surfaces of pores.

Abstract: An apparatus for remotely monitoring the level of lubricant in a sump of an internal combustion engine on a vehicle and remotely transferring lubricant from the engine sump including a lubricant tank mounted on the vehicle external to the vehicle's engine. The lubricant tank and the engine may each contain a quantity of gas above the respective lubricant levels in the tank and the sump with the pressure of gas contained in the lubricant tank being regulated relative to the pressure of gas contained in the engine such that the level of lubricant in the tank is indicative of and varies along with the level of lubricant in the engine sump. The apparatus may include an equalization connection between the sump and the tank and an evacuation connection to the tank for transferring lubricant from the tank. The tank may include a plurality of internal chambers situated for lubricant to flow between them to prevent lubricant from being drawn out of the sump below a lubricant low-level limit of the sump.

Abstract: A grayscale mask for imaging operations, including a substrate layer and a mask layer having a plurality of apertures forming a mask pattern to form a grayscale image. Each edge of each aperture includes a plurality segments forming a serrated edge, resulting in mixed edge diffraction. The apertures may be in an irregular and non-symmetric pattern and may be of variable size. A random diffusing layer may be in proximity to or integral with the substrate layer. The grayscale mask may be used for generating an optical element by printing the initial grayscale mask onto a photoresist layer and transferring the photoresist pattern onto a transparent layer and the mask may include areas or layers of variable transmission. Also described are methods for diffractive intensity averaging, diffractive error diffusion, diffractive spatial dithering, and diffractive intensity averaging.

Abstract: Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 5-carbon sugar, sugar alcohol, or lactic acid are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol. A process for the synthesis of PG from lactate or lactic acid is also described.

Abstract: A suspension for and a method for suspending a vehicle having a body is provided. The suspension includes a first wheel assembly suspension and a second wheel assembly suspension. The first wheel assembly suspension extends between a first wheel assembly and the body. The first wheel assembly suspension includes an instant center. The second wheel assembly suspension extends between a second wheel assembly and the body. The second wheel assembly suspension includes an instant center. The first wheel assembly and the second wheel assembly are aligned so that a vertical centerline of each wheel assembly lies within a vertical plane that extends therebetween. In one embodiment, the instant center of each wheel assembly suspension is located within the vertical plane, below a roll center located within the vertical plane.

Abstract: A method and package for controlled metered dispensing of a fluid product contained in the package having a metered dispensing system, each time the package is opened or uncapped are disclosed. By the present method and package, the maximum amount of product that can be dispensed is limited to a single metered dose after each uncapping of the package. Specifically, the metered dispensing system is configured to allow dispensing of only a single metered dose of a liquid, viscous liquid, gel, paste, or semi-solid product contained in the package and to prevent further dispensing of additional doses of product until at least one specific and deliberate step is taken that re-activates or re-engages the dispensing system. Such deliberate step is preferably one that occurs through natural use of the package, such as re-capping the open package after one single dose has been dispensed. Only after the open package has been re-capped can the next dose of product be available for dispensing.

Abstract: The broach assembly includes alternate spacers and cutters arranged in a sub-assembly having a lead at a leading end and a lag at a trailing end. The cutters have side margins in excess of the margins of the spacers for cutting material from the dovetail slots of the turbine wheel as the broach assembly passes through the slots. The bottom or apices of each spacer and cutter are tapered to form a continuously tapered surface along the bottom of the broach assembly. Upon passing the broach assembly through the slot, the assembly is progressively displaced in a radial outward direction to progressively cut the active dovetail slot surfaces. Shims may be disposed in the bottom of the slot to further displace the broach assembly radially outwardly in multiple passes.

Abstract: Featured are a device, system and method for dissipating at least some heat energy generated by one or more heat generating components of a flywheel energy storage system (FESS). The method includes providing a heat pipe member, having first and second ends, and a heat dissipating member thermally engaged with the heat pipe member second end and configured to transfer heat energy therefrom. The method also includes thermally engaging the heat pipe member first end to the FESS so that at least some heat energy generated by the FESS heat generating component is communicated to the first end and thence through the heat pipe member to the heat dissipating member. Further, the method includes locating the heat dissipating member in a heat sink remote from the FESS.

Abstract: The present invention is directed toward methods and apparatuses for encapsulating a microelectronic die or another type of microelectronic device. One aspect of the present invention is directed toward packaging a microelectronic die that is attached to either a first surface or a second surface of a substrate. The die can be encapsulated by positioning the die in a cavity of a substrate and sealing the substrate to the substrate. The method can further include injecting an encapsulation compound into the cavity at a first end of the substrate to move along the first surface of the substrate. This portion of the compound defines a first flow of compound along the first surface that moves in a first direction from a first end of the substrate toward a second end of the substrate.

Abstract: A device extends the storage bed of a vehicle and creates a storage receptacle at multiple locations on top of the storage bed. Adjustable length side walls are pivotally attached to an end wall to form an open top box. Two walls pivotally attached to each other and to the end wall allow formation of a storage receptacle when desired. The adjustability of the side walls permits the open top box, whether it is used to extend the storage bed, create a storage receptacle on top of the storage bed or both, to make optimal use of the storage space between the wheel wells of the vehicle and its raised tailgate, as well as to make optimal use of the additional storage bed space created by lowering the tailgate. Storage receptacles created by the open top box may be subdivided into multiple smaller storage receptacles.

Abstract: A process for fabricating system-on-chip devices which contain embedded DRAM along with other components such as SRAM or logic circuits is disclosed. Local interconnects, via salicides and tungsten are formed subsequent to polysilicon plugs required for the operation of the DRAM and SRAM or logic. Also disclosed are systems-on-chips MIM/MIS capacitive devices produced by the inventive process.

Abstract: A communication access chassis having a general purpose computing platform provides communication access between remote users and computer network via the public telephone network. The general purpose computing platform is connected to an internal chassis bus complex transmitting incoming calls between a telephone line interface and a signal conversion system and between the signal conversion system and a local area network interface. The computing platform has a conventional microprocessor and local or peripheral memory storage devices and implements a commercially available open network operating system such as Windows NT™. By virtue of the ability of the general purpose computing platform to run network server programs locally, i.e.

Abstract: A ram plate which allows easy lifting and dropping of the plate even when a complete seal has been made with high-viscosity liquids inside a barrel. The system contains two alternative methods of depressurizing the internal liquids in order to more efficiently avoid vacuum and suction effect when the user attempts to raise the plate. The bleed stick components of the plate are completely independent of vent ports components. Such bleed stick components are levers which, when depressed, will move a cover and expose the internal liquids to outside air pressure via air vents. The vent port components operate through both gravity and potential energy of an internal spring, which place a given amount of downward pressure on a pneumatic cylinder which may or may not be enough pressure to move the cylinder and expose a vent to the outside atmosphere pressure.