Patents by Inventor A. Tom Oomens

A. Tom Oomens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant respiratory syncytial viruses with deleted surface glycoprotein genes and uses thereof
    Patent number: 7041489
    Abstract: The present invention provides recombinant respiratory syncytial viruses (RSV) in which all of the surface glycoprotein genes encoding the attachment protein G, the fusion protein F, and the Small Hydrophobic protein SH are deleted. The genes are replaced by a chimeric gene encoding a heterologous entry protein derived from the Vesicular Stomatitis Virus G protein or GP64 of baculovirus. Alternatively, the replacement proteins are provided in trans. Marker genes such as those encoding ?-glucuronidase (GUS) and green fluorescent protein (EGFP) are also added to the upstream and downstream side of the hybrid gene for easy detection. These infectious recombinant respiratory syncytial viruses offer alternatives and improvements as vaccine candidates.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 9, 2006
    Assignee: The UAB Research Foundation
    Inventors: Gail W. Wertz, Alexander George Megaw, A. Tom Oomens
  • Recombinant respiratory syncytial viruses with deleted surface glycoprotein genes and uses thereof
    Publication number: 20030072773
    Abstract: The present invention provides recombinant respiratory syncytial viruses (RSV) in which all of the surface glycoprotein genes encoding the attachment protein G, the fusion protein F, and the Small Hydrophobic protein SH are deleted. The genes are replaced by a chimeric gene encoding a heterologous entry protein derived from the Vesicular Stomatitis Virus G protein or GP64 of baculovirus. Alternatively, the replacement proteins are provided in trans. Marker genes such as those encoding &bgr;-glucuronidase (GUS) and green fluorescent protein (EGFP) are also added to the upstream and downstream side of the hybrid gene for easy detection. These infectious recombinant respiratory syncytial viruses offer alternatives and improvements as vaccine candidates.
    Type: Application
    Filed: October 1, 2002
    Publication date: April 17, 2003
    Inventors: Gall W. Wertz, Alexander George Megaw, A. Tom Oomens