Patents by Inventor A. Varier Radhika

A. Varier Radhika has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof
    Patent number: 7402706
    Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 ?M) and pCAF (IC50-15 ?M). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: July 22, 2008
    Assignee: Jawaharlal Nehru Centre for Advanced Scientific Research
    Inventors: Kundu Tapas Kumar, Karanam Balasubramanyam, Kempegowda Mantelingu, Altaf Mohammad, Venkatesh Swaminathan, A. Varier Radhika