Abstract: Toothbrush sanitizing devices for home use. The devices include an outer housing, an inner housing, a cover and a sanitizing assembly. The inner housing is removably retained within the outer housing by an interference fit. The cover member is removably supported by the inner and/or outer housings such that the cover member and the outer housing form an enclosure, with the inner housing inside the enclosure. The inner housing has upwardly extending centering flanges for properly positioning the cover on the housings. The inner and outer housings form longitudinal slots to receive the handles of toothbrushes. The sanitizing assembly is attached to the inner housing and includes an ultra-violet lamp, an electronic printed circuit board, a microswitch and a switch member. The switch member is pivotably mounted in one of the centering flanges and is moved from the off to the on position when the cover is properly placed on the housings.