Abstract: A method comprises detecting a removable media device being coupled to an external device port of a digital device having an operating system and a file system, authenticating a password to access the removable media device, causing redirection code to be temporarily generated on the digital device, intercepting with the redirection code a data request, determining to allow the data request based on a security policy, allowing the operating system or file system to provide the data based on the determination, detecting the removable media device being removed from the digital device; and terminating the at least a portion of the redirection code.

Abstract: The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV)vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.

Abstract: A CPA ultrashort pulse laser system is configured with a beam splitter dividing each ultrashort pulse from a seed laser into at least two replicas which propagate along respective replica paths. Each replica path includes an upstream dispersive element stretching respective replicas to different pulse durations. The optical switches are located in respective replica paths upstream or downstream from upstream dispersive elements. Each optical switch is individually controllable to operate at a high switching speed between “on” and “off” positions so as to selectively block one of the replicas or temporally separate the replicas at the output of the switching assembly. The replicas are so stretched that a train of high peak power ultrashort pulses each are output with a pulse duration selected from a fs ns range and peak power of up to a MW level.

Abstract: The ultra-short pulse chirped pulse amplification (CPA) laser system and method of operating CPA laser system include outputting nearly transform limited (TL) pulses by a mode locked laser. The system and method further include temporarily stretching the TL pulses by a first Bragg grating providing thus each stretched pulse with a chirp which is further compensated for in a second Bragg grating operating as as a compressor. The laser system and method further include a pulse shaping unit measuring a spectral phase across the recompressed pulse and further adjusting the deviation of the measured spectral phase from that of the TL pulse by generating a corrective signal. The corrective signal is applied to the array of actuators coupled to respective segments of one of the BGs which are selectively actuated to induce the desired phase change, with the one BG thus operating as both stretcher/compressor and pulse shaper.

Abstract: In various embodiments, a method comprises detecting a removable media device coupled to a digital device, authenticating a password to access the removable media device, injecting redirection code into the digital device, intercepting, with the redirection code, a request for data, determining to allow the request for data based on a security policy, and providing the data based on the determination. The method may further comprise selecting the security policy from a plurality of security policies based, at least in part, on the password and/or filtering the content of the requested data. Filtering the content may comprise scanning the data for malware. Filtering the content may also comprise scanning the data for confidential information.

Abstract: A laser system and method. In one example, the laser system includes an optical pulse stretcher configured to stretch pulse durations of an input train of input pulses to produce a train of stretched laser pulses, a pulse replicator module configured to increase a pulse repetition rate of the train of stretched laser pulses to produce a modified pulse train of laser light, a fiber power amplifier configured to amplify the modified pulse train to produce amplified laser pulses, and a pulse compressor that temporally compresses the amplified laser pulses to produce amplified and compressed laser pulses. The system may further include a nonlinear frequency conversion stage comprising at least one nonlinear crystal.

Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).

Abstract: The ultrafast pulse fiber laser system is configured with scalable output power and operative to reduce degradation of pulse integrity. The disclosed laser system is configured to suppress the pulse distortion through improvement of initial pulse contrast between main and side pulses and improved pulse shape using chirped pulse amplification and a fast intensity modulator driver by a corrected electrical signal that is generated from the original optical signal. The structure providing the improvement includes the photodiode, which is operative to measure the chirped optical pulse and convert it to the electrical signal, and analog electronics that quickly converts the electrical signal to the required signal that suppress the side pulses.

Abstract: In various embodiments, a method comprises detecting a removable media device coupled to a digital device, authenticating a password to access the removable media device, injecting redirection code into the digital device, intercepting, with the redirection code, a request for data, determining to allow the request for data based on a security policy, and providing the data based on the determination. The method may further comprise selecting the security policy from a plurality of security policies based, at least in part, on the password and/or filtering the content of the requested data. Filtering the content may comprise scanning the data for malware. Filtering the content may also comprise scanning the data for confidential information.

Abstract: The ultrafast pulse fiber laser system is configured with scalable output power and operative to reduce degradation of pulse integrity. The disclosed laser system is configured to suppress the pulse distortion through improvement of initial pulse contrast between main and side pulses and improved pulse shape using chirped pulse amplification and a fast intensity modulator driver by a corrected electrical signal that is generated from the original optical signal. The structure providing the improvement includes the photodiode, which is operative to measure the chirped optical pulse and convert it to the electrical signal, and analog electronics that quickly converts the electrical signal to the required signal that suppress the side pulses.

Abstract: The ultra-short pulse chirped pulse amplification (CPA) laser system and method of operating CPA laser system include outputting nearly transform limited (TL) pulses by a mode locked laser. The system and method further include temporarily stretching the TL pulses by a first Bragg grating providing thus each stretched pulse with a chirp which is further compensated for in a second Bragg grating operating as as a compressor. The laser system and method further include a pulse shaping unit measuring a spectral phase across the recompressed pulse and further adjusting the deviation of the measured spectral phase from that of the TL pulse by generating a corrective signal. The corrective signal is applied to the array of actuators coupled to respective segments of one of the BGs which are selectively actuated to induce the desired phase change, with the one BG thus operating as both stretcher/compressor and pulse shaper.

Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).

Abstract: In various embodiments, a method comprises detecting a removable media device coupled to a digital device, authenticating a password to access the removable media device, injecting redirection code into the digital device, intercepting, with the redirection code, a request for data, determining to allow the request for data based on a security policy, and providing the data based on the determination. The method may further comprise selecting the security policy from a plurality of security policies based, at least in part, on the password and/or filtering the content of the requested data. Filtering the content may comprise scanning the data for malware. Filtering the content may also comprise scanning the data for confidential information.

Abstract: In various embodiments, a method comprises detecting a removable media device coupled to a digital device, authenticating a password to access the removable media device, injecting redirection code into the digital device, intercepting, with the redirection code, a request for data, determining to allow the request for data based on a security policy, and providing the data based on the determination. The method may further comprise selecting the security policy from a plurality of security policies based, at least in part, on the password and/or filtering the content of the requested data. Filtering the content may comprise scanning the data for malware. Filtering the content may also comprise scanning the data for confidential information.

Abstract: The time to test integrated circuits is increasing as a function of the complexity of integrated circuits and processes used to fabricate the integrated circuits. Embodiments of this disclosure include systems and methods for reducing the time to integrated circuits by reducing the number of devices individually modeled. Embodiments can reduce the number of modeled devices by combining two or more devices into a single combined device that models all discrete devices, but in a reduced form.

Abstract: A fiber Raman laser is configured with a microstructured double clad passive fiber which has an inner cladding receiving and guiding a high intensity pump light. The double-clad passive fiber farther has a eon surrounded by the inner cladding and an outer cladding. An arrangement of air holes is configured to define the inner, waveguiding cladding so that an NA of the latter varies between about 0.25-0.9 allowing this to reduce the diameter of the inner cladding. The passive fiber is characterized by a substantial overlap between the pump light and 1st stokes in the care and further includes an absorber operative to substantially suppress the signal light at the 2nd strokes so that the Ge-doped fiber outputs a SM, bright radiation at up to kW levels.

Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Abstract: A laser illuminated projector system is configured with multiple Red, Green and Blue laser sources. The Green laser source has an all fiber master oscillator power amplifier configuration in which pump light is coupled into the output end of the fiber amplifier in a counter-propagation direction rendering the structure of the Green source and therefore projector system compact. The Green laser source is operative to emit signal light pulses at about 1064 nm wavelength with a pulse repetition reaching of up to about 3000 kHz, pulse duration between about a 100 fm to about 100 psec, an average power between 1.5 W to above 30 W, a peak power above 5 MW, a pulse energy exceeding 100 ?J and a beam quality parameter M2 ranging between 1.2 and 1.5. The thus configured Green laser source substantially reduces speckle otherwise visible on the laser illuminated screen.

Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Abstract: A fiber Raman laser is configured with a microstructured double clad passive fiber which has an inner cladding receiving and guiding a high intensity pump light. The double-clad passive fiber farther has a eon surrounded by the inner cladding and an outer cladding. An arrangement of air holes is configured to define the inner, waveguiding cladding so that an NA of the latter varies between about 0.25-0.9 allowing this to reduce the diameter of the inner cladding. The passive fiber is characterized by a substantial overlap between the pump light and 1st stokes in the care and further includes an absorber operative to substantially suppress the signal light at the 2nd strokes so that the Ge-doped fiber outputs a SM, bright radiation at up to kW levels.