Abstract: Systems and methods for distributed order fulfillment are disclosed. Real-time fulfillment data indicating unavailability of a first item identified in an order is received from a first computing device. The real-time fulfillment data is generated in response to an input received by the first computing device. Order update data indicating unavailability of the first item and one or more substitute items is transmitted to a second computing device. The order update data causes the second computing device to generate an interface including the substitute items and a portion of the order update data. A substitute response from the second computing device. In response to receiving the substitute response, The selected substitute item is substituted in place of the first item during fulfillment when the substitute response indicates acceptance the substitute item and the first item is removed from the order when the substitute response indicates rejection of the substitute items.