Patents by Inventor Aarne Fleischer

Aarne Fleischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF SCREENING APOPTOSIS MODULATING COMPOUNDS, COMPOUNDS IDENTIFIED BY SAID METHODS AND USE OF SAID COMPOUNDS AS THERAPEUTIC AGENTS
    Publication number: 20070184435
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type, said method comprising: (a) culturing cells of said particular cell-type under non apoptotic conditions and culturing cells of said particular cell-type under apoptotic conditions, and (b) determining subcellular localisation of said cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of said cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that said cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in said particular cell-type.
    Type: Application
    Filed: April 5, 2007
    Publication date: August 9, 2007
    Applicants: INSTITUT PASTEUR, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alphonse GARCIA, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer
  • Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
    Patent number: 7217534
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic conditions and culturing cells of the particular cell-type under apoptotic conditions, and (b) determining subcellular localization of the cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of the cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that the cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in the particular cell-type.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: May 15, 2007
    Assignees: Institut Pasteur, Consejo Superior de Investigaciones Cientificas, Centre National de la Recherche Scientifque
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer
  • Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
    Publication number: 20060040331
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type, said method comprising: (a) culturing cells of said particular cell-type under non apoptotic conditions and culturing cells of said particular cell-type under apoptotic conditions, and (b) determining subcellular localisation of said cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of said cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that said cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in said particular cell-type.
    Type: Application
    Filed: May 31, 2005
    Publication date: February 23, 2006
    Applicants: INSTITUT PASTEUR, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer