Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A metal matrix composite to high tolerate wear as a property has been produced by infiltration casting of a Fe Alloy and a spinel ceramic by using a material design for i) metal transport phenomena conditions, ii) predefined wetting and capillarity and iii) processing child insert/mother casting methodology to produce a final casting in shape and form to meet the needs of a mining end user.

Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.

Abstract: An exemplary embodiment of the present disclosure provides a wearable gait monitoring system for monitoring characteristics of an animal pulling a payload. The system can comprise and inertial measurement unit (IMU), a load sensor, and a display. The IMU can be configured to be positioned proximate the animal and configured to generate IMU data indicative of an acceleration and rotation of the animal. The load sensor can be configured to generate force data indicative of a force exerted on the payload by the animal. The display can be configured to display load and gait information to a user, wherein the load and gait information can be based on the IMU data and the force data.

Abstract: An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Abstract: A module mat system with first layer that is joined to a second layer by fusion welding, hot welding, hand welding, seam welding, heat pressing, or other methods know to those having skill in the art. Each layer has a central core with a first cellular structure formed from ribs extending from the interior surface. The cross section of the ribs in the central core of the first layer matches the cross section of the ribs in the central core of the second layer such that when fusion welded together the ribs of the central core of the first layer weld to the ribs of the central core of the second layer.

Abstract: A fastening device system for connection at least a first and a second overlapping mats placed on the ground wherein the first mat is aligned over at least one connecting hole of the second mat, the fastening device system comprising, a housing having a first half and a second half wherein the first half and second half are attached together forming the housing. A pin having a foot disposed at the lower end thereof and a shaft having a helical shelf that engages the helical channel of the housing. The pin is configured so that when it rotates 90° in one direction to the housing the pin draws the foot closer to bottom of housing and provides at least one locking position of the foot and locking the foot in place.

Abstract: A rotary propulsion engine system designed to propel a craft. Such a rotary propulsion engine system comprises a power supply, a counterrotating disc assembly including two axially and rotatably connected discs, a drive mechanism to rotate the two counterrotating discs, an axle assembly, at least two reaction masses or armatures, at least two reaction mass driver assemblies, and at least two travel pathways for the reaction masses. Reaction masses are fired into a rotational environment wherein the kinetic energy of the reaction masses is recycled, thereby reducing or eliminating the need for chemical propellant-based propulsion systems, and transporting heavy, finite, and expensive fuels for combustion.

Abstract: A traction mat system and a method of manufacturing comprising a mat having a grip layer adhered to or mate integral to the surface of the mat. The grip layer can be a textured material foil sheet combined to a top surface and/or a bottom surface of the mat system. The texture of the grip layer is retained when the mat is contoured with a raised pattern to give the entire surface of the mat a texture to improve traction and grip. A method of manufacturing comprises a traction mat system wherein the traction mat can comprise of manufacturing step for placing a grip layer on the mat surfaces, for placing the foil sheet and/or aggregate on the mat. Each operation can be performed for both surfaces simultaneously or can be its own operation such as one surface at a time, or both surfaces at once.

Abstract: A rotary propulsion engine system designed to propel a craft. Such a rotary propulsion engine system comprises at least two reaction masses or armatures, at least two reaction mass driver assemblies, at least two travel pathways for said reaction masses or armatures, two counterrotating discs housing an equal number of the at least two said reaction mass driver assemblies, and a counterbalancing means used to maintain a balanced distribution of masses about the axis of rotation of each counterrotating disc in order to maintain a zero horizontal torque sum as each reaction mass or armature moves along its ballistic trajectory. Reaction masses are fired into a rotational environment wherein the kinetic energy of said reaction masses is recycled, thereby reducing or eliminating the need for chemical propellant-based propulsion systems, and transporting heavy, finite, and expensive fuels for combustion.

Abstract: Systems, methods, and tangible non-transitory machine readable medium are provided. A system includes a gas turbine system configured to produce power by combusting a fuel. The system further includes a controller configured to control the gas turbine system via an operating 2-dimensional surface area and a setpoint, wherein the operating 2-dimensional surface area comprises a plurality of limits defining bounds for the operating 2-dimensional surface area, and wherein the setpoint is configured to be disposed inside the operating 2-dimentionsal surface area or on the limits.

Abstract: A tangible non-transitory computer readable medium may include instructions to analyze a first signal indicative of a speed of a turbine system and transform the first signal into a second signal. The tangible non-transitory computer-readable medium may also include instructions to transmit the second signal to control a speed of the turbine system by actuating a field device. Actuating the field device may include controlling a fluid level in a torque converter mechanically coupled to the turbine system, and the speed may be below a minimum setpoint of the turbine system.

Abstract: A method of testing a gas turbine is provided. The gas turbine includes a first compressor and an expansion turbine coupled by a drive shaft. The method includes operating the gas turbine and a second compressor at a first steady load and a first steady drive shaft speed. The second compressor is rigidly coupled to the drive shaft. The method also includes changing a load of the second compressor by a known amount, and measuring a time required for the gas turbine to stabilize at a second steady load and a second steady drive shaft speed in response to the changed load of the second compressor.

Abstract: A control apparatus for angling guide vanes of a torque converter is provided and includes a modeling unit configured to receive current condition data, to determine a current input power supplied by a starting motor from the current condition data and to output a result of the determination as a control signal and a controller, which is coupled to the modeling unit and thereby receptive of the control signal. The controller is configured to execute a comparison of the current input power with a rating of the starting motor and to angle the guide vanes of the torque converter at an angle in accordance with a result of the comparison.

Abstract: A charging station for an electric vehicle may include a charge head configured to engage with the charging blade of the vehicle to transfer power. The charge head may include a housing with a central cavity extending along its longitudinal axis and a plurality of electrode holders. Each electrode holder may include an electrode configured to transform from an extended configuration when the charging blade is not positioned in the central cavity to a retracted configuration when the charging blade is positioned in the central cavity. In its extended configuration, the electrode may extend into the central cavity from a side wall of the housing, and in the retracted configuration, at least a portion of the electrode may retract into the housing. Each electrode may also include a plurality of springs configured to bias the electrode in the extended configuration.

Abstract: Aspects of the disclosure include apparatuses and program products for recovering speed in a driveline assembly. An apparatus in one embodiment may include: a sensor measuring a shaft speed of a rotatable shaft within a driveline assembly, wherein the driveline assembly includes: a load coupled to the rotatable shaft, a primary power source coupled to the load through the rotatable shaft to deliver a first power output to the load, and a secondary power source coupled to the load through the rotatable shaft to deliver a second power output to the load, wherein the second power output is less than the first power output; and a controller in communication with the secondary power source and the sensor, wherein the controller increases the second power output in response to the shaft speed being less than a minimum speed threshold.