Abstract: A compound having the following structure of Formula (I): or a stereoisomer of the compound, tautomer of the compound, pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, A, X, Z, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: Instruments, systems, and methods for securing anchors, elastomeric devices, and other elements in bone. In one example, an instrument includes a collar movable between a locked configuration that prevents an insertion shaft of the instrument from translating relative to a drive shaft of the instrument and an unlocked configuration that does not prevent the insertion shaft from translating relative to the drive shaft. In another example, an instrument for securing an elastomeric device to bone includes a lock movable between locked and unlocked configurations (e.g. similar to or the same as the collar in the previous example) that facilitates insertion of the elastomeric device into a bone opening when the lock is in the locked configuration, and subsequent insertion of a bone implant into the bone opening when the lock is in the unlocked configuration.

Abstract: A method for providing pink noise and improving computational efficiency including providing NS stochastic signal generators, generating a respective first random number g with variance ? and generating a respective second random number u for each respective stochastic signal generator at each discrete time n, comparing the respective second random number u with an update probability for the respective stochastic signal generator at each discrete time n, if the respective u is greater than the update probability, then not changing a respective output of the respective stochastic signal generator, if the respective u is less than or equal to the update probability, then updating the respective output of the respective stochastic signal generator to be equal to the first random number, and summing at each discrete time n the respective output of each of the NS stochastic signal generators.

Abstract: A system is provided for generating electricity from a fluid pressurized via a natural resource such as air compressed through a windmill, the compressed air stored in tanks by a windmill operated compressor, where the stored compressed air is then used to operate a turbine. The turbine has a nozzle configured to increase velocity of the compressed air entering the turbine. The rotor of the turbine has flat annular discs each set apart from one another by spacers to form a rotor stack with no central shaft. Permanent magnets are positioned radially about the end of the rotor stack. The magnets are arranged such that their poles radially alternate to interact with static wire coils positioned about the ends of the rotor stack to produce alternating current electricity. The compressed air enters the turbine at a tangent along the outer periphery of the rotor and exit axially through a central exhaust port.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: A system is provided for generating electricity from a fluid pressurized via a natural resource such as air compressed through a windmill, the compressed air stored in tanks by a windmill operated compressor, where the stored compressed air is then used to operate a turbine. The turbine has a nozzle configured to increase velocity of the compressed air entering the turbine. The rotor of the turbine has flat annular discs each set apart from one another by spacers to form a rotor stack with no central shaft. Permanent magnets are positioned radially about the end of the rotor stack. The magnets are arranged such that their poles radially alternate to interact with static wire coils positioned about the ends of the rotor stack to produce alternating current electricity. The compressed air enters the turbine at a tangent along the outer periphery of the rotor and exit axially through a central exhaust port.

Abstract: A spinal implant may be used to stabilize a portion of a spine. The implant may promote bone growth between adjacent vertebrae that fuses the vertebrae together. An implant may include an opening through a height of a body of the implant. The body of the implant may include curved sides. A top and/or a bottom of the implant may include protrusions that contact and/or engage vertebral surfaces to prevent backout of the implant from the disc space. A variety of instruments may be used to prepare a disc space and insert an implant. The instruments may include, but are not limited to, a distracter, a rasp, and one or more guides. The implant and instruments may be supplied in an instrument kit.

Abstract: A set of screws sized and configured for fixing a Jones fracture in a fifth metatarsal bone of a patient by preserving a bone thread path. Each screw has a low profile head on a trailing end, a thread portion on a leading portion, and a smooth shank portion between the head portion and the thread portion. A first screw has a thread major diameter of between about 4.4-4.6 mm, a second screw a thread major diameter of between about 5.4-5.6 mm, and a third screw a thread major diameter of between about 6.4-6.6 mm. The thread portion of all the screws in the set has a set of identical thread profile characteristics comprising a pitch, a leading edge angle, a trailing edge angle, a leading edge radius, a trailing edge radius, and a land. Each screw size is provided in various preferred lengths.

Abstract: A set of screws sized and configured for fixing a Jones fracture in a fifth metatarsal bone of a patient by preserving a bone thread path. Each screw has a low profile head on a trailing end, a thread portion on a leading portion, and a smooth shank portion between the head portion and the thread portion. A first screw has a thread major diameter of between about 4.4-4.6 mm, a second screw a thread major diameter of between about 5.4-5.6 mm, and a third screw a thread major diameter of between about 6.4-6.6 mm. The thread portion of all the screws in the set has a set of identical thread profile characteristics comprising a pitch, a leading edge angle, a trailing edge angle, a leading edge radius, a trailing edge radius, and a land. Each screw size is provided in various preferred lengths.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: A spinal implant may be used to stabilize a portion of a spine. The implant may promote bone growth between adjacent vertebrae that fuses the vertebrae together. An implant may include an opening through a height of a body of the implant. The body of the implant may include curved sides. A top and/or a bottom of the implant may include protrusions that contact and/or engage vertebral surfaces to prevent backout of the implant from the disc space. A variety of instruments may be used to prepare a disc space and insert an implant. The instruments may include, but are not limited to, a distractor, a rasp, and one or more guides. The implant and instruments may be supplied in an instrument kit.

Abstract: A spinal implant may be used to stabilize a portion of a spine. The implant may promote bone growth between adjacent vertebrae that fuses the vertebrae together. An implant may include an opening through a height of a body of the implant. The body of the implant may include curved sides. A top and/or a bottom of the implant may include protrusions that contact and/or engage vertebral surfaces to prevent backout of the implant from the disc space. A variety of instruments may be used to prepare a disc space and insert an implant. The instruments may include, but are not limited to, a distractor, a rasp, and one or more guides. The implant and instruments may be supplied in an instrument kit.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

Abstract: A set of screws sized and configured for fixing a Jones fracture in a fifth metatarsal bone of a patient by preserving a bone thread path. Each screw has a low profile head on a trailing end, a thread portion on a leading portion, and a smooth shank portion between the head portion and the thread portion. A first screw has a thread major diameter of between about 4.4-4.6 mm, a second screw a thread major diameter of between about 5.4-5.6 mm, and a third screw a thread major diameter of between about 6.4-6.6 mm. The thread portion of all the screws in the set has a set of identical thread profile characteristics comprising a pitch, a leading edge angle, a trailing edge angle, a leading edge radius, a trailing edge radius, and a land. Each screw size is provided in various preferred lengths.

Abstract: An endoscope lens cleaning system for use in removing surgical debris from the objective lens of an endoscope has a sheath adapted to receive the endoscope, carrying a control switch and having an open distal end in fluid communication with a proximally mounted luer lock for removably engaging the distal luer connection of a tubing set. The tubing set is connected to and engaged with a peristaltic pump including a microprocessor or controller adapted to respond to actuation of the control switch and execute software including program steps for operation of the pump. The pump controller is programmed to execute a scrub cycle each time the clinician actuates the control switch mounted on the preferably disposable sheath.