Patents by Inventor Aaron Christoph Schmidt

Aaron Christoph Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transmembrane pH-gradient polymersomes and their use in the scavenging of ammonia and its methylated analogs
    Patent number: 11026891
    Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: June 8, 2021
    Assignee: Eth Zurich
    Inventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt
  • TRANSMEMBRANE PH-GRADIENT POLYMERSOMES AND THEIR USE IN THE SCAVENGING OF AMMONIA AND ITS METHYLATED ANALOGS
    Publication number: 20190183800
    Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 20, 2019
    Applicant: ETH Zurich
    Inventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt