Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: A pouch or pocket may act as a container and may be used to securely hold objects (e.g., cell phone, keys, wallet, etc.) during athletic activity (e.g., running). The pouch may be a standalone item or integrally formed as part of other items. The pouch may hold the object to be stored in place within the pouch or pocket. The pouch may provide some cushioning or impact force attenuation to protect the object being held within the pouch or pocket. Additionally, the pouch may be attached to a garment, such as running clothes. The pouch includes an outer envelope sealable by a closure and a one-way valve with foam layers located inside the pouch. After the object is placed in the pouch, the closure is closed, and the air within the pouch is expelled via the one-way valve by compressing the foam layers from the outside.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: Footwear or other foot-receiving devices include various conforming fit, stability, and/or “locked down” feel features. The uppers (or foot-covering components) for such articles of footwear (or other foot-receiving devices) may include one or more of: (a) an upper shell defining an interior chamber, wherein the upper shell includes a plantar support surface and sidewalls extending from an outer perimeter of the plantar support surface; (b) a bootie component (e.g., formed as a sock or sock-like garment) received in the interior chamber; (c) one or more foot wrapping bands; and/or (d) an interior midsole within the bootie component. The bootie component and/or the foot wrapping band(s) may be secured to the upper shell at a location inside an outer perimeter of the plantar support surface of the upper shell and beyond the bight line between the sidewalls of the upper and the plantar support surface.

Abstract: A pouch or pocket may act as a container and may be used to securely hold objects (e.g., cell phone, keys, wallet, etc.) during athletic activity (e.g., running). The pouch may be a standalone item or integrally formed as part of other items. The pouch may hold the object to be stored in place within the pouch or pocket. The pouch may provide some cushioning or impact force attenuation to protect the object being held within the pouch or pocket. Additionally, the pouch may be attached to a garment, such as running clothes. The pouch includes an outer envelope sealable by a closure and a one-way valve with foam layers located inside the pouch. After the object is placed in the pouch, the closure is closed, and the air within the pouch is expelled via the one-way valve by compressing the foam layers from the outside.

Abstract: Footwear or other foot-receiving devices include various conforming fit, stability, and/or “locked down” feel features. The uppers (or foot-covering components) for such articles of footwear (or other foot-receiving devices) may include one or more of: (a) an upper shell defining an interior chamber, wherein the upper shell includes a plantar support surface and sidewalls extending from an outer perimeter of the plantar support surface; (b) a bootie component (e.g., formed as a sock or sock-like garment) received in the interior chamber; (c) one or more foot wrapping bands; and/or (d) an interior midsole within the bootie component. The bootie component and/or the foot wrapping band(s) may be secured to the upper shell at a location inside an outer perimeter of the plantar support surface of the upper shell and beyond the bight line between the sidewalls of the upper and the plantar support surface.

Abstract: A pouch or pocket may act as a container and may be used to securely hold objects (e.g., cell phone, keys, wallet, etc.) during athletic activity (e.g., running). The pouch may be a standalone item or integrally formed as part of other items. The pouch may hold the object to be stored in place within the pouch or pocket. The pouch may provide some cushioning or impact force attenuation to protect the object being held within the pouch or pocket. Additionally, the pouch may be attached to a garment, such as running clothes. The pouch includes an outer envelope sealable by a closure and a one-way valve with foam layers located inside the pouch. After the object is placed in the pouch, the closure is closed, and the air within the pouch is expelled via the one-way valve by compressing the foam layers from the outside.

Abstract: An apparatus utilizes multiple strain gauge (“SG”) sensing units which are each disposed adjacent an inner surface of the device housing. Electrical voltage generated by the SGs is amplified by one or more amplifiers to maximize the resolution between a voltage output of an SG when in a non-pressed state and a voltage output of the SG when in a pressed state. Additionally, an electronic circuit is configured to identify a baseline voltage output for an SG over a period of time for comparing to a voltage output for the SG when the SG is in a pressed state such that the pressed state of the SG can be identified by the electronic circuit by comparing a current output voltage of the SG to the identified baseline voltage.

Abstract: Embodiments are directed towards to managing operations for an organization. An operation engine may be employed to provide operations metrics based on events and resolution actions associated with an incident. Update information may be provided to console modules included in operations command consoles (OCCs) each console module may include module views. The console modules may be employed to provide data objects to the module views. The module views may be employed to provide different visualizations of the incident based on a role that may be associated with the console modules. An OCC may be employed to provide other resolution actions to the operations engine and then that operations engine may provide additional update information to the console modules based on the other resolution actions.

Abstract: A pouch or pocket may act as a container and may be used to securely hold objects (e.g., cell phone, keys, wallet, etc.) during athletic activity (e.g., running). The pouch may be a standalone item or integrally formed as part of other items. The pouch may hold the object to be stored in place within the pouch or pocket. The pouch may provide some cushioning or impact force attenuation to protect the object being held within the pouch or pocket. Additionally, the pouch may be attached to a garment, such as running clothes. The pouch includes an outer envelope sealable by a closure and a one-way valve with foam layers located inside the pouch. After the object is placed in the pouch, the closure is closed, and the air within the pouch is expelled via the one-way valve by compressing the foam layers from the outside.

Abstract: A locking apparatus (3) for securing a luggage article (1) comprises a mechanism for unlocking the locking apparatus (3) including at least one moveable member (11, 12, 13) which is moveable in an unlocking operation. The locking apparatus (3) has at least one detector arrangement (42, 49, 55a, 55b) associated with at least one moveable member (11, 12, 13) by at least one linkage (19, 37a, 37b, 41) between the detector arrangement (42, 49, 55a, 55b) and the moveable member (11, 12, 13), the linkage (19, 37a, 37b, 41) triggers the detector arrangement (42, 49, 55a, 55b) upon the movement of the moveable member (11, 12, 13).