Abstract: Embodiments of the subject matter disclosed herein relate to controlling engine operating points and power for full throttle command in an off-highway vehicle, such as a diesel electric haul truck, to increase fuel efficiency. In one example, a system includes an engine and a controller. The controller is configured to determine a target engine horsepower and associated target engine speed, command the engine to operate at a first engine speed above the target engine speed, adjust a load placed on the engine to reach the target engine speed, and command the engine to operate at a second engine speed to reach the target engine horsepower.

Abstract: Embodiments of the subject matter disclosed herein relate to controlling engine operating points and power for full throttle command in an off-highway vehicle, such as a diesel electric haul truck, to increase fuel efficiency. In one example, a system includes an engine and a controller. The controller is configured to determine a target engine horsepower and associated target engine speed, command the engine to operate at a first engine speed above the target engine speed, adjust a load placed on the engine to reach the target engine speed, and command the engine to operate at a second engine speed to reach the target engine horsepower.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: Embodiments of the subject matter disclosed herein relate to controlling engine operating points and power for full throttle command in an off-highway vehicle, such as a diesel electric haul truck, to increase fuel efficiency. In one example, a system includes an engine and a controller. The controller is configured to determine a target engine horsepower and associated target engine speed, command the engine to operate at a first engine speed above the target engine speed, adjust a load placed on the engine to reach the target engine speed, and command the engine to operate at a second engine speed to reach the target engine horsepower.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: Embodiments of the subject matter disclosed herein relate to controlling engine operating points and power for full throttle command in an off-highway vehicle, such as a diesel electric haul truck, to increase fuel efficiency. In one example, a system includes an engine and a controller. The controller is configured to determine a target engine horsepower and associated target engine speed, command the engine to operate at a first engine speed above the target engine speed, adjust a load placed on the engine to reach the target engine speed, and command the engine to operate at a second engine speed to reach the target engine horsepower.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: A system and method for auxiliary clutch failure detection determines a difference between a first output power of a powered system when a clutch system is controlled to engage and drive a load at a first output of the load and a second output power of the powered system when the clutch system is controlled to drive the load at a larger, second output. A control signal indicative of clutch failure is generated responsive to the difference being less than a designated threshold. The control signal may be used to implement one or more remedial actions.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: A method and system for making a golf ball core is disclosed. The method may generally include forming a golf ball core out of a raw core material. The golf ball core may be rapidly heated to begin curing (or vulcanizing) from the outermost surface toward the center of the golf ball core. Before curing the entire golf ball core, the golf ball core may be quenched to stop the curing process. As a result, the golf ball core may include an outer cured zone and an inner uncured zone. In this state, the golf ball core may be incorporated into a finished golf ball to be sold to consumers. Following a set of instructions provided with the golf ball, the consumer may heat the golf ball to customize the properties of the golf ball core, and, thus, the characteristics of the golf ball.

Abstract: A method and system for making a golf ball core is disclosed. The method may generally include forming a golf ball core out of a raw core material. The golf ball core may be rapidly heated to begin curing (or vulcanizing) from the outermost surface toward the center of the golf ball core. Before curing the entire golf ball core, the golf ball core may be quenched to stop the curing process. As a result, the golf ball core may include an outer cured zone and an inner uncured zone. In this state, the golf ball core may be incorporated into a finished golf ball to be sold to consumers. Following a set of instructions provided with the golf ball, the consumer may heat the golf ball to customize the properties of the golf ball core, and, thus, the characteristics of the golf ball.

Abstract: A system and method for auxiliary clutch failure detection determines a difference between a first output power of a powered system when a clutch system is controlled to engage and drive a load at a first output of the load and a second output power of the powered system when the clutch system is controlled to drive the load at a larger, second output. A control signal indicative of clutch failure is generated responsive to the difference being less than a designated threshold. The control signal may be used to implement one or more remedial actions.

Abstract: Embodiments of the subject matter disclosed herein relate to controlling engine operating points and power for full throttle command in an off-highway vehicle, such as a diesel electric haul truck, to increase fuel efficiency. In one example, a system includes an engine and a controller. The controller is configured to determine a target engine horsepower and associated target engine speed, command the engine to operate at a first engine speed above the target engine speed, adjust a load placed on the engine to reach the target engine speed, and command the engine to operate at a second engine speed to reach the target engine horsepower.

Abstract: A monitoring system and method determine a consumption metric representative of one or more of an amount of fuel consumed or an amount of energy consumed by a vehicle during travel over a route. The consumption metric is independent of one or more of vehicle load or elevation change over the route. The system and method optionally can determine a route condition metric representative of a condition of a route traveled upon by a vehicle. The route condition metric is based on a comparison between an actual grade of the route at one or more locations along the route and an estimated grade of the route at the one or more locations.

Abstract: A high performance golf ball made in part of a modified high Mooney viscosity rubber. The modified high Mooney viscosity rubber has less than about 20 phr oil and is high Mooney viscosity rubber having a Mooney viscosity at least about 40 blended with between about 1 phr and about 10 phr of process oil and between about 0.05 phr and 5 phr of peptizing agent.

Abstract: A method and system for making a golf ball core is disclosed. The method may generally include forming a golf ball core out of a raw core material. The golf ball core may be rapidly heated to begin curing (or vulcanizing) from the outermost surface toward the center of the golf ball core. Before curing the entire golf ball core, the golf ball core may be quenched to stop the curing process. As a result, the golf ball core may include an outer cured zone and an inner uncured zone. In this state, the golf ball core may be incorporated into a finished golf ball to be sold to consumers. Following a set of instructions provided with the golf ball, the consumer may heat the golf ball to customize the properties of the golf ball core, and, thus, the characteristics of the golf ball.