Patents by Inventor Aaron D. Gitler

Aaron D. Gitler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of TDP-43 Mediated Toxicity and Methods of Use Thereof for Identifying Agents Having Efficacy for the Treatment and Prevention of Proteinopathies
    Publication number: 20120237499
    Abstract: Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 20, 2012
    Inventors: Aaron D. Gitler, Andrew Elden
  • Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20110142789
    Abstract: Compositions and methods for diagnosis and treatment of ALS are provided.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 16, 2011
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Aaron D. Gitler, Nancy Bonini
  • MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20110064722
    Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Application
    Filed: December 22, 2008
    Publication date: March 17, 2011
    Applicant: Whitehead Institute for Miomedical Reasearch
    Inventors: Susan L. Lindquist, Aaron D. Gitler
  • YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR
    Publication number: 20110053857
    Abstract: Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis.
    Type: Application
    Filed: February 13, 2009
    Publication date: March 3, 2011
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Susan L. Lindquist, Aaron D. Gitler
  • MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20090304664
    Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Application
    Filed: May 12, 2006
    Publication date: December 10, 2009
    Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar
  • MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20090099069
    Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Application
    Filed: December 1, 2005
    Publication date: April 16, 2009
    Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, THE CURATORS OF THE UNIVERSITY MISSOURI
    Inventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar, Antony A. Cooper, Cole M. Haynes