Abstract: A prosthesis for the CMC joint of a thumb therefore includes a metacarpal component that has a first articular surface and a stem configured for insertion and anchoring into a metacarpal canal of a thumb metacarpal bone. The stem has a dorsal surface and an opposing volar surface. Each of the dorsal surface and the volar surface is defined by a proximal region and a distal region. The proximal region of the volar surface has a volar taper angle that is greater than distal region of the volar surface and a dorsal taper angle of proximal region of the dorsal surface is less than the volar taper angle of the proximal region of the volar surface. The prosthesis further includes a trapezial component having a second articular surface cooperating with the first articular surface. The trapezial component is configured to be coupled (e.g., anchored) to a trapezium bone.

Abstract: An orthopedic external fixation system may include a distal bar having a curvature that varies along its length, an uncurved proximal bar, a plurality of proximal embedding members, and a plurality of distal embedding members. The proximal and the distal embedding members, sized and shaped for embedding in bone, may attach directly or indirectly to the proximal bar and the distal bar, respectively.

Abstract: Methods and compositions for treating bone disorders are disclosed.

Abstract: An orthopedic external fixation system may include a distal bar having a curvature that varies along its length, an uncurved proximal bar, a plurality of proximal embedding members, and a plurality of distal embedding members. The proximal and the distal embedding members, sized and shaped for embedding in bone, may attach directly or indirectly to the proximal bar and the distal bar, respectively.

Abstract: An orthopedic external fixation system may include a distal bar having a curvature that varies along its length, an uncurved proximal bar, a plurality of proximal embedding members, and a plurality of distal embedding members. The proximal and the distal embedding members, sized and shaped for embedding in bone, may attach directly or indirectly to the proximal bar and the distal bar, respectively.

Abstract: An orthopedic external fixation system may include a distal bar having a curvature that varies along its length, an uncurved proximal bar, a plurality of proximal embedding members, and a plurality of distal embedding members. The proximal and the distal embedding members, sized and shaped for embedding in bone, may attach directly or indirectly to the proximal bar and the distal bar, respectively.

Abstract: Methods and compositions are provided for the treatment of defects and disease involving osteoporosis or osteopenic conditions. The methods comprise applying to the site of osteoporotic or osteopenic conditions a composition comprising a BMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utlizing BMP-3 conditions.

Abstract: Methods and compositions are provided for the treatment of defects and disease involving osteoporosis, or osteopenic conditions. The methods comprises applying to the site of osteoporotic or osteopenic conditions a composition comprising aBMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utilizing BMP-3 compositions.