Patents by Inventor Aaron DELOUGHERY

Aaron DELOUGHERY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250177569
    Abstract: Provided herein are compositions, systems and methods for allele-specific editing of a target gene in a cell, comprising contacting the cell with an effector protein or a polynucleotide encoding the same, and a guide nucleic acid or a polynucleotide encoding the same. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering the NRAS or KRAS gene.
    Type: Application
    Filed: December 3, 2024
    Publication date: June 5, 2025
    Inventors: Subhadra JAYARAMAN RUKMINI, Shreyans SADANGI, Lucas Benjamin HARRINGTON, Pei-Qi LIU, Benjamin Julius RAUCH, William Douglass WRIGHT, Stepan TYMOSHENKO, Wiputra Jaya HARTONO, Aaron DELOUGHERY
  • Publication number: 20250145974
    Abstract: Provided herein are compositions, systems, and methods comprising engineered effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: November 6, 2024
    Publication date: May 8, 2025
    Inventors: Wiputra Jaya HARTONO, Pei-Qi LIU, Lucas Benjamin HARRINGTON, Aaron DELOUGHERY, William Douglass WRIGHT, Stepan TYMOSHENKO, Benjamin Julius RAUCH
  • Publication number: 20240384247
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: May 20, 2024
    Publication date: November 21, 2024
    Inventors: Aaron DELOUGHERY, Benjamin RAUCH, Clarissa Oriel RHINES, Stepan TYMOSHENKO, Fnu YUNANDA, Lucas Benjamin HARRINGTON
  • Publication number: 20240366678
    Abstract: Provided herein are compositions, systems, and methods for engineering hematopoietic stem cells that engineered by using polypeptides, such as effector proteins, and guide nucleic acids. Also, provided herein are the engineered hematopoietic stem cells, methods of manufacturing such hematopoietic stem cells, and methods of treating a disease or disorder using such hematopoietic stem cells.
    Type: Application
    Filed: May 2, 2024
    Publication date: November 7, 2024
    Inventors: Mark Alan DEWITT, Siming XU, William Douglass WRIGHT, Stepan TYMOSHENKO, Benjamin Julius RAUCH, Wiputra Jaya HARTONO, Aaron DELOUGHERY, Lucas Benjamin HARRINGTON
  • Publication number: 20240226327
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.
    Type: Application
    Filed: September 18, 2023
    Publication date: July 11, 2024
    Inventors: Timothy Robert ABBOTT, Aaron DELOUGHERY, David PAEZ-ESPINO, Benjamin Julius RAUCH
  • Publication number: 20240191281
    Abstract: The present disclosure provides compositions and methods of use for a Type VI CRISPR/Cas nuclease. Type VI CRISPR/Cas nucleases are able to bind to a target nucleic acid, thereby activating trans-collateral nuclease activity on nucleic acid reports. Furthermore, the present disclosure provides methods to modify ribonucleic acid sequences using the programmable nucleases disclosed herein.
    Type: Application
    Filed: August 2, 2023
    Publication date: June 13, 2024
    Inventors: Benjamin Julius RAUCH, Aaron DELOUGHERY, Matan DRORY RETWITZER, David PAEZ-ESPINO, Caleb TRECAZZI, Lucas Benjamin HARRINGTON, Janice Sha CHEN, James Paul BROUGHTON, Clarissa Oriel RHINES, William Douglass WRIGHT, Matthew VEROSLOFF, Carley Gelenter HENDRIKS
  • Publication number: 20240191280
    Abstract: The present disclosure describes CRISPR/Cas proteins and guide RNA combinations that are capable of modifying nucleic acids at high temperatures. These compositions are especially useful for systems and methods of nucleic acid detection, including diagnostic devices.
    Type: Application
    Filed: November 10, 2023
    Publication date: June 13, 2024
    Inventors: William Douglass WRIGHT, Benjamin Julius RAUCH, Aaron DELOUGHERY, James Paul BROUGHTON
  • Publication number: 20240175059
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: December 4, 2023
    Publication date: May 30, 2024
    Inventors: Aaron DELOUGHERY, Matan Drory Retwitzer, Lucas Benjamin Harrington, Wiputra Jaya Hartono, Alexander Richard Neckelmann, David Paez-Espino, Benjamin Julius Rauch, Clarissa Oriel Rhines, Stepan Tymoshenko, Fnu Yunanda, William Douglass Wright
  • Publication number: 20240131187
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.
    Type: Application
    Filed: September 17, 2023
    Publication date: April 25, 2024
    Inventors: Timothy Robert ABBOTT, Aaron DELOUGHERY, David PAEZ-ESPINO, Benjamin Julius RAUCH
  • Publication number: 20230332218
    Abstract: The present disclosure provides compositions and methods of use for Type V CRISPR/Cas proteins. Type V CRISPR/Cas nucleases may be configured to bind nucleic acids in a sequence specific manner. Such a binding event may activate the Type V CRISPR/Cas nuclease for sequence non-specific trans-collateral cleavage of single-stranded nucleic acids. Provided herein are methods leveraging Type V CRISPR/Cas nuclease trans-collateral cleavage for identifying nucleic acid sequences.
    Type: Application
    Filed: April 21, 2021
    Publication date: October 19, 2023
    Inventors: Benjamin RAUCH, William Douglass WRIGHT, Wiputra HARTONO, Lucas Benjamin HARRINGTON, Clarissa Oriel RHINES, Janice Sha CHEN, James Paul BROUGHTON, Aaron DELOUGHERY
  • Publication number: 20230323406
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: June 12, 2023
    Publication date: October 12, 2023
    Inventors: Aaron DELOUGHERY, Matan DRORY RETWITZER, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, Alexander Richard NECKELMANN, David PAEZ-ESPINO, Benjamin Julius RAUCH, Clarissa Oriel RHINES, Stepan TYMOSHENKO, Fnu YUNANDA, William Douglass WRIGHT
  • Publication number: 20230257739
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: September 23, 2022
    Publication date: August 17, 2023
    Inventors: Aaron DELOUGHERY, David PAEZ-ESPINO, Benjamin Julius RAUCH, Clarissa Oriel RHINES, Stepan TYMOSHENKO, Fnu YUNANDA, Matan DRORY RETWITZER, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, William Douglass WRIGHT, Alexander Richard NECKELMANN
  • Publication number: 20230203481
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: November 7, 2022
    Publication date: June 29, 2023
    Inventors: Rohan GROVER, Clarissa Oriel RHINES, Aaron DELOUGHERY, Benjamin Julius RAUCH, William Douglass WRIGHT, David PAEZ-ESPINO, Lucas Benjamin HARRINGTON
  • Publication number: 20230068771
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: May 17, 2022
    Publication date: March 2, 2023
    Inventors: Benjamin Julius RAUCH, Aaron DELOUGHERY, William Douglass WRIGHT, David PAEZ-ESPINO, Clarissa Oriel RHINES, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO