Patents by Inventor Aaron DELOUGHERY

Aaron DELOUGHERY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROGRAMMABLE NUCLEASES AND METHODS OF USE
    Publication number: 20240173433
    Abstract: The present disclosure provides compositions and methods of use for Type V CRISPR/Cas proteins. Type V CRISPR/Cas proteins may be configured to bind and modify nucleic acids in a sequence specific manner.
    Type: Application
    Filed: October 4, 2023
    Publication date: May 30, 2024
    Inventors: Benjamin Julius RAUCH, Aaron Deloughery, William Douglass Wright, David Paez-Espino
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20240175059
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: December 4, 2023
    Publication date: May 30, 2024
    Inventors: Aaron DELOUGHERY, Matan Drory Retwitzer, Lucas Benjamin Harrington, Wiputra Jaya Hartono, Alexander Richard Neckelmann, David Paez-Espino, Benjamin Julius Rauch, Clarissa Oriel Rhines, Stepan Tymoshenko, Fnu Yunanda, William Douglass Wright
  • EFFECTOR PROTEINS, EFFECTOR PARTNERS, COMPOSITIONS, SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20240131187
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.
    Type: Application
    Filed: September 17, 2023
    Publication date: April 25, 2024
    Inventors: Timothy Robert ABBOTT, Aaron DELOUGHERY, David PAEZ-ESPINO, Benjamin Julius RAUCH
  • Effector proteins and methods of use
    Patent number: 11814620
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: November 14, 2023
    Assignee: Mammoth Biosciences, Inc.
    Inventors: Benjamin Julius Rauch, Aaron DeLoughery, William Douglass Wright, David Paez-Espino, Clarissa Oriel Rhines, Lucas Benjamin Harrington, Wiputra Jaya Hartono
  • CASY PROGRAMMABLE NUCLEASES AND RNA COMPONENT SYSTEMS
    Publication number: 20230332218
    Abstract: The present disclosure provides compositions and methods of use for Type V CRISPR/Cas proteins. Type V CRISPR/Cas nucleases may be configured to bind nucleic acids in a sequence specific manner. Such a binding event may activate the Type V CRISPR/Cas nuclease for sequence non-specific trans-collateral cleavage of single-stranded nucleic acids. Provided herein are methods leveraging Type V CRISPR/Cas nuclease trans-collateral cleavage for identifying nucleic acid sequences.
    Type: Application
    Filed: April 21, 2021
    Publication date: October 19, 2023
    Inventors: Benjamin RAUCH, William Douglass WRIGHT, Wiputra HARTONO, Lucas Benjamin HARRINGTON, Clarissa Oriel RHINES, Janice Sha CHEN, James Paul BROUGHTON, Aaron DELOUGHERY
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20230323406
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: June 12, 2023
    Publication date: October 12, 2023
    Inventors: Aaron DELOUGHERY, Matan DRORY RETWITZER, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, Alexander Richard NECKELMANN, David PAEZ-ESPINO, Benjamin Julius RAUCH, Clarissa Oriel RHINES, Stepan TYMOSHENKO, Fnu YUNANDA, William Douglass WRIGHT
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20230257739
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: September 23, 2022
    Publication date: August 17, 2023
    Inventors: Aaron DELOUGHERY, David PAEZ-ESPINO, Benjamin Julius RAUCH, Clarissa Oriel RHINES, Stepan TYMOSHENKO, Fnu YUNANDA, Matan DRORY RETWITZER, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, William Douglass WRIGHT, Alexander Richard NECKELMANN
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20230203481
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: November 7, 2022
    Publication date: June 29, 2023
    Inventors: Rohan GROVER, Clarissa Oriel RHINES, Aaron DELOUGHERY, Benjamin Julius RAUCH, William Douglass WRIGHT, David PAEZ-ESPINO, Lucas Benjamin HARRINGTON
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20230068771
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: May 17, 2022
    Publication date: March 2, 2023
    Inventors: Benjamin Julius RAUCH, Aaron DELOUGHERY, William Douglass WRIGHT, David PAEZ-ESPINO, Clarissa Oriel RHINES, Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO