Abstract: A hand-washing apparatus configured to simultaneously wash hands includes an enclosure with openings for each hand, and members for finger support and thumb support. The finger support member extends upward from the enclosure's base and the thumb support member extends along a direction different from the finger support member. The finger support has a surface for receiving and orienting fingers of both hands at corresponding locations inside the enclosure. Similarly, the thumb support has a surface for receiving and orienting both thumbs. The finger-support surface has two recess sets, each of which receives fingers of one hand. First and second spray-nozzles are directed to irrigate the fingers and thumbs respectively.

Abstract: A hand-washing apparatus configured to simultaneously wash hands includes an enclosure with openings for each hand, and members for finger support and thumb support. The finger support member extends upward from the enclosure's base and the thumb support member extends along a direction different from the finger support member. The finger support has a surface for receiving and orienting fingers of both hands at corresponding locations inside the enclosure. Similarly, the thumb support has a surface for receiving and orienting both thumbs. The finger-support surface has two recess sets, each of which receives fingers of one hand. First and second spray-nozzles are directed to irrigate the fingers and thumbs respectively.

Abstract: This invention discloses a peristaltic pump composed of a two-stage linear peristaltic pump mechanism, which engages in different functions, charging and pumping a fluid to a patient. This peristaltic pump is capable of restoring the crushed tubing, caused by repeated compression or crushing of the tubing by peristaltic fingers, to its original circular cross sectional area so that it can provide a precise flow rate. The two-stage linear peristaltic pump mechanism substantially improves the consistency of a flow rate over time and extends the usefulness of peristaltic pumps to applications where they could not otherwise be used.

Abstract: A hand washing apparatus configured to simultaneously wash both a left hand and a right hand includes an enclosure having an exterior surface and an interior space. The exterior surface having a front face and first and second side faces located on opposites sides of the front face. The enclosure includes a first opening in the first side face of the exterior surface for receiving a left hand for insertion into the interior space and a second opening in the second side face of the exterior surface for receiving a right hand for insertion into the interior space. There is a first digit support member located within the interior space having a surface for receiving and orienting a first subset of digits of the first and second hands in a predetermined position within the interior space and a second digit support member located within the interior space having a surface for receiving and orienting a second subset of digits of the first and second hands in a predetermined position within the interior space.

Abstract: This invention discloses a peristaltic pump composed of a two-stage linear peristaltic pump mechanism, which engages in different functions, charging and pumping a fluid to a patient. This peristaltic pump is capable of restoring the crushed tubing, caused by repeated compression or crushing of the tubing by peristaltic fingers, to its original circular cross sectional area so that it can provide a precise flow rate. The two-stage linear peristaltic pump mechanism substantially improves the consistency of a flow rate over time and extends the usefulness of peristaltic pumps to applications where they could not otherwise be used.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Abstract: An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.

Abstract: An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Abstract: A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.

Abstract: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.

Abstract: Described is a composition with low toxicity comprising an amphipathic compound and a polycation, useful for delivering siRNA to a cell. The composition may be used in the process of delivering a siRNA to an animal cell, or more particularly a mammal cell, in a multi-well format.

Abstract: Described is a composition with low toxicity comprising an amphipathic compound and a polycation, useful for delivering siRNA to a cell. The composition may be used in the process of delivering a siRNA to an animal cell, or more particularly a mammal cell, in a multi-well format.

Abstract: Described is a process for delivering an inhibitor directed against an expressible nucleic acid sequence in a mammal to inhibit RNA function. An RNA function inhibiting sequence that is specific to the expressible nucleic acid sequence in the mammal is made and inserted into a blood vessel in the mammal. The inhibitor is delivered to a cell wherein expression of the nucleic acid sequence is inhibited.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Abstract: A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.

Abstract: The present invention relates to methods for delivering a genetic immunogen, comprising a nucleic acid capable of expressing an antigen, optionally complexed with a polymer. The nucleic acid is delivered to the host via an intravascular, oral, buccal, dermal, nasal, or rectal route, where the complex transfects lymphoid tissues resulting in expression of an encoded antigen and induction of an antigen-specific immune response.

Abstract: A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.