Patents by Inventor Aaron G. Schmidt

Aaron G. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RATIONALLY DESIGNED IMMUNOGENS
    Publication number: 20250032605
    Abstract: The invention relates to a monomeric immunogen comprising one receptor binding domain of a Coronavirus spike protein, wherein the receptor binding domain includes at least 4 non-native. N-linked, glycosylation sites.
    Type: Application
    Filed: December 5, 2022
    Publication date: January 30, 2025
    Inventors: Aaron G. SCHMIDT, Blake M. HAUSER, Timothy M. CARADONNA
  • MOLECULAR GRAFTING OF COMPLEX, BROADLY NEUTRALIZING ANTIBODY EPITOPES
    Publication number: 20200231630
    Abstract: Described herein is a chimeric epitope comprising (a) a conserved donor receptor binding site (RBS) or a neutralizing epitope, or a functional fraction thereof, and (b) an acceptor molecular scaffold or fragment thereof. Another aspect provides a chimeric epitope comprising (a) a conserved donor receptor binding site (RBS) derived from circulating H1 influenza, and (b) an acceptor molecular scaffold derived from non-circulating influenza. Further, compositions and methods for inducing an immune response and vaccination are described herein.
    Type: Application
    Filed: September 28, 2018
    Publication date: July 23, 2020
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Aaron G. SCHMIDT, Goran BAJIC, Max J. MARON
  • BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
    Publication number: 20180230201
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 16, 2018
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody, Thomas B. Kepler, Aaron G. Schmidt
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
    Patent number: 9718873
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: August 1, 2017
    Assignees: Duke University, Children's Medical Center Corporation
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. A. Moody, Thomas B. Kepler, Aaron G. Schmidt
  • BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
    Publication number: 20140302043
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: February 3, 2014
    Publication date: October 9, 2014
    Applicants: DUKE UNIVERSITY, CHILDREN'S HOSPITAL BOSTON
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. Anthomy Moody, Thomas B. Kepler, Aaron G. Schmidt