Patents by Inventor Aaron George Winters

Aaron George Winters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-TERMINAL ANTIBODY DISCOVERY METHODS AND SINGLE CELL ASSAYS
    Publication number: 20240103009
    Abstract: Provided herein are methods of monitoring for the production of select antibodies in a non-human animal, comprising (a) immunizing a non-human animal with an immunogen; (b) obtaining a blood sample comprising antibody secreting cells (ASCs) from said non-human animal; and (c) individually assaying ASCs present in the blood sample, or a fraction thereof, for the production of select antibodies. Methods of guiding antibody production in a non-human animal for the production of select antibodies are also provided. In exemplary embodiments, the method comprises performing a cycle of (a) to (c), as above, and repeating the cycle when the percentage of ASCs producing select antibodies is below a threshold. In various aspects, the cycle is repeated until the percentage of ASCs producing select antibodies is at or above a threshold. Single cell assays are further provided herein.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 28, 2024
    Applicant: AMGEN INC.
    Inventors: Karyn E. MCFADDEN, Brian M. CHAN, Christopher MURAWSKY, Aaron George WINTERS, Daniel SANTOS
  • SYSTEMS FOR PERFORMING CELLULAR ANALYSIS AND RELATED DEVICES FOR CONDITIONING ENVIRONMENTS ADJACENT CHIPS IN SUCH SYSTEMS
    Publication number: 20220226829
    Abstract: Systems for performing cellular analysis and related devices for conditioning environments adjacent chips in such systems. A device for conditioning an environment adjacent a chip in a system for performing cellular analysis, the device includes a cover for being disposed adjacent the chip and comprising a planar body having a top surface, a bottom surface, and an outer edge surface. The cover includes a central opening extending between the top surface and the bottom surface and bounded by an inner edge surface of the cover. The cover also includes a fluid inlet extending into the body from the outer edge surface between the top surface and the bottom surface the fluid inlet arranged to accept a gas to be delivered to the central opening. The cover also includes a plurality of fluid outlets defined in the inner edge surface and in fluid communication with the fluid inlet. The plurality of fluid outlets are arranged to receive the gas from the fluid inlet and exhaust the gas into the central opening.
    Type: Application
    Filed: June 4, 2020
    Publication date: July 21, 2022
    Inventors: Craig Michael SCHULZ, Justin James PROVCHY, Aaron George WINTERS
  • HEPCIDIN, HEPCIDIN ANTAGONISTS AND METHODS OF USE
    Publication number: 20140286953
    Abstract: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.
    Type: Application
    Filed: December 11, 2013
    Publication date: September 25, 2014
    Applicant: Amgen Inc.
    Inventors: Barbra Sasu, Mitsuru Haniu, Thomas Charles Boone, Xiao-juan Bi, Grace Ki Jeong Lee, Tara Arvedson, Aaron George Winters, Keegan Cooke, Jackie Z. Sheng
  • Hepcidin, hepcidin antagonists and methods of use
    Patent number: 8629250
    Abstract: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: January 14, 2014
    Assignee: Amgen Inc.
    Inventors: Barbra Sasu, Mitsuru Haniu, Thomas Charles Boone, Xiao-juan Bi, Grace Ki Jeong Lee, Tara Arvedson, Aaron George Winters, Keegan Cooke, Jackie Z. Sheng
  • WISE BINDING AGENTS AND EPITOPES
    Publication number: 20120288507
    Abstract: The present invention relates to binding agents for WISE, and includes methods for their manufacture and use.
    Type: Application
    Filed: December 17, 2010
    Publication date: November 15, 2012
    Applicant: Amgen Inc.
    Inventors: Xueming Qian, Aaron George Winters, Michelle Hortter, Kevin Graham, Mei-Mei Tsai
  • Wise binding agents and epitopes
    Patent number: 8309092
    Abstract: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: November 13, 2012
    Assignee: Amgen Inc.
    Inventors: Xueming Qian, Kevin Graham, Grant Shimamoto, Barbara S. Tipton, Mei-Mei Tsai, Aaron George Winters, Li Zhang
  • ANTI-C MPL ANTIBODIES
    Publication number: 20120269814
    Abstract: The present invention provides compositions and methods utilizing antagonistic antibodies which specifically bind to human c-MPL (e.g., TPO-R).
    Type: Application
    Filed: November 10, 2010
    Publication date: October 25, 2012
    Applicant: AMGEN INC.
    Inventors: Ping Wei, Aaron George Winters, Christina Abbott
  • WISE BINDING AGENTS AND EPITOPES
    Publication number: 20120003237
    Abstract: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
    Type: Application
    Filed: September 15, 2011
    Publication date: January 5, 2012
    Applicant: AMGEN INC.
    Inventors: Xueming QIAN, Kevin Graham, Grant Shimamoto, Barbara S. Tipton, Mei-Mei Tsai, Aaron George Winters, Li Zhang
  • EPITOPES
    Publication number: 20110305702
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: April 28, 2011
    Publication date: December 15, 2011
    Applicants: AMGEN INC., UCB PHARMA S.A.
    Inventors: HSIENG S. LU, CHRISTOPHER J. PASZTY, MARTYN KIM ROBINSON, ALISTAIR J. HENRY, KELLY SUE WARMINGTON, JOHN LATHAM, ALASTAIR LAWSON, DAVID G. WINKLER, AARON GEORGE WINTERS
  • Wise binding agents and epitopes
    Patent number: 8043620
    Abstract: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: October 25, 2011
    Assignee: Amgen Inc.
    Inventors: Xueming Qian, Kevin Graham, Grant Shimamoto, Barbara S. Tipton, Mei-Mei Tsai, Aaron George Winters, Li Zhang
  • Sclerostin epitopes
    Patent number: 8003108
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: August 23, 2011
    Assignees: Amgen Inc., UCB SA
    Inventors: Hsieng Sen Lu, Christpher Paszty, Martyn Kim Robinson, Alistair James Henry, Kelly Sue Warmington, John Latham, Alastair Lawson, David Winkler, Aaron George Winters
  • BINDING AGENTS
    Publication number: 20090304713
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: November 24, 2008
    Publication date: December 10, 2009
    Applicants: AMGEN INC., UCB PHARMA S.A.
    Inventors: Christoper Paszty, Martin Kim Robinson, Kevin Graham, Alistair James Henry, Kelly Sue Hoffmann, John Latham, Hsieng Sen Lu, Alastair Lawson, Andy Popplewell, Wenyan Shen, David G. Winkler, Aaron George Winters
  • Sclerostin-binding antibody
    Patent number: 7592429
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: September 22, 2009
    Assignees: UCB SA, Amgen Inc.
    Inventors: Christopher Paszty, Martyn Kim Robinson, Kevin Graham, Alistair James Henry, Kelly Sue Hoffmann, John Latham, Hsieng Sen Lu, Alastair Lawson, Andy Popplewell, Wenyan Shen, David Winkler, Aaron George Winters
  • WISE BINDING AGENTS AND EPITOPES
    Publication number: 20090130114
    Abstract: The present invention relates to binding agents for WISE, and includes for their manufacture and use.
    Type: Application
    Filed: November 21, 2008
    Publication date: May 21, 2009
    Inventors: Xueming Qian, Kevin Graham, Grant Shimamoto, Barbara S. Tipton, Mei-Mei Tsai, Aaron George Winters, Li Zhang