Abstract: A novel method of increasing longevity by improving the processivity, fidelity, and activity of the telomerase enzyme is provided by agents which introduce trivalent cations such as scandium 3+ into the nuclei of cells, whereupon there occurs substitution of the trivalent cation into the place of the natural divalent cations such as magnesium or calcium or manganese. This substitution optimizes the adherence of the telomerase enzyme to its nucleic acid template with the result that cellular replicative senescence is delayed and deferred in various cell types. The trivalent cations can be introduced topically, orally as a food additive or supplement, or as a medication for oral, intramuscular, intrathecal or intravenous administration.

Abstract: A positron based system is disclosed which extracts electric power from matter-antimatter annihilation reactions between electrons and positrons. In one embodiment, for storage and distribution of electric power, a solar array provides power to a cyclotron that produces the positron emitter 52Manganese. The positron emitting 52Mn is incorporated into spinel ferrite nanoparticles capable of suspension in an electrolyte fluid. This liquid pourable energy source is deployed to operate an internal annihilation engine, and to support a system for production of further positrons by a chain reaction pair production method.

Abstract: The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present invention are particularly useful for providing local radiotherapy. The present invention also concerns methods of using the compositions of the invention, particularly for radiotherapy.

Abstract: An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for achieving efficient transfection of associated nucleic acid into a cell.

Abstract: A novel means of pharmaceutical delivery for therapy of prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g., intramuscular injections of a nerve adhesion molecule in coupled particle comprising a physiologically active substance or a diagnostic marker.

Abstract: A novel means of pharmaceutical delivery for therapy or prophylaxis or to assist surgical or diagnostic operations on the living body is provided by agents which undergo neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g., intramuscular injections of a nerve adhesion molecule comprising a physiologically active substance or a diagnostic marker.

Abstract: The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present invention are particularly useful for providing local radiotherapy. The present invention also concerns methods of using the compositions of the invention, particularly for radiotherapy.

Abstract: An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for achieving efficient transfection of associated nucleic acid into a cell.

Abstract: An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for achieving efficient transfection of associated nucleic acid into a cell.

Abstract: A novel means of pharmaceutical delivery for therapy of prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g. intramuscular injections of a nerve adhesion molecule in coupled particle comprising a physiologically active substance or a diagnostic marker.