Patents by Inventor Aaron H. PHILLIPS

Aaron H. PHILLIPS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered conformationally-stabilized proteins
    Patent number: 9139863
    Abstract: Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 22, 2015
    Assignee: Genentech, Inc.
    Inventors: Jacob E. Corn, Yingnan Zhang, Aaron H. Phillips
  • ENGINEERED CONFORMATIONALLY-STABILIZED PROTEINS
    Publication number: 20130281314
    Abstract: Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Jacob E. CORN, Yingnan ZHANG, Aaron H. PHILLIPS