Patents by Inventor Aaron I. Vinik

Aaron I. Vinik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAY FOR THE DETECTION OF FACTORS THAT MODULATE THE EXPRESSION OF INGAP
    Publication number: 20120058078
    Abstract: A reporter construct contains mammalian INGAP 5?-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5?-regulatory region or a fragment thereof.
    Type: Application
    Filed: August 1, 2011
    Publication date: March 8, 2012
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • ASSAY FOR THE DETECTION OF FACTORS THAT MODULATE THE EXPRESSION OF INAGP
    Publication number: 20090156458
    Abstract: A reporter construct contains mammalian INGAP 5?-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5?-regulatory region or a fragment thereof.
    Type: Application
    Filed: April 4, 2008
    Publication date: June 18, 2009
    Applicant: GMP ENDOTHERAPEUTICS, INC.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • INGAP displacement assays
    Patent number: 7442774
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: October 28, 2008
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • Composition and method for treating diabetes
    Publication number: 20080171704
    Abstract: The present invention comprises dosing regimens and formulations of islet cell neogenesis associated protein (INGAP) and INGAP Peptide. The formulation disclosed herein is shown have acceptable stability as a pharmaceutical composition. Further, the formulation is able to regenerate functional islets.
    Type: Application
    Filed: December 4, 2007
    Publication date: July 17, 2008
    Inventors: Aaron I. Vinik, Lawrence Rosenberg, Gary Pittenger, David Taylor-Fishwick, Michael Salem, Scott Mohrland
  • Regulatory sequences for modulation of INGAP expression and reporter constructs
    Patent number: 7355024
    Abstract: A an isolated mammalian INGAP 5?-regulatory region comprising at least about nucleotides 1-3137 of SEQ ID NO: 2 (SEQ ID NO: 23).
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: April 8, 2008
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • Assay for anti-INGAP antibodies
    Patent number: 7166439
    Abstract: A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: January 23, 2007
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • INGAP displacement assays
    Patent number: 6986994
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: January 17, 2006
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • Composition and method for treating diabetes
    Publication number: 20040132644
    Abstract: The present invention comprises dosing regimens and formulations of islet cell neogenesis associated protein (INGAP) and INGAP Peptide. The formulation disclosed herein is shown have acceptable stability as a pharmaceutical composition. Further, the formulation is able to regenerate functional islets.
    Type: Application
    Filed: September 24, 2002
    Publication date: July 8, 2004
    Applicant: The Procter & Gamble Company
    Inventors: Aaron I. Vinik, Lawrence Rosenberg, Gary Pittenger, David Taylor-Fishwick, Michael Salem, Scott Mohrland
  • Assay for the detection of factors that modulate the expression of INGAP
    Publication number: 20030207301
    Abstract: A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof.
    Type: Application
    Filed: January 9, 2003
    Publication date: November 6, 2003
    Applicant: The Procter & Gamble Company
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • Assay for anti-INGAP antibodies
    Publication number: 20030166031
    Abstract: A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 4, 2003
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • INGAP displacement assays
    Publication number: 20020127624
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Application
    Filed: January 7, 2002
    Publication date: September 12, 2002
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • Ingap protein involved in pancreatic islet neogenesis
    Patent number: 5840531
    Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: November 24, 1998
    Assignees: MoGill University, Eastern Virginia Medical School of the Medicine College of Hampton Roads
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff, Lawrence Rosenberg, William P. Duguid
  • Ingap protein involved in pancreatic islet neogenesis
    Patent number: 5834590
    Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: November 10, 1998
    Assignee: Eastern Virginia Medical School of the Medical College of Hampton Roads
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff, Lawrence Rosenberg, William P. Duguid
  • High level of expression of ingap in bacterial and euraryotic cells
    Patent number: 5804421
    Abstract: Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: September 8, 1998
    Assignee: Eastern Virginia Medical School of the Medical College fo Hampton Roads
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff-Phail, Scott W. Barlow
  • INGAP protein involved in pancreatic islet neogenesis
    Patent number: RE39062
    Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: April 11, 2006
    Assignees: McGill Unviersity, Eastern Virginia Medical School of the Medical College of Hampton Roads
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff-Phail, Lawrence Rosenberg, Jean T. S. Duguid, William P. Duguid
  • INGAP protein involved in pancreatic islet neogenesis
    Patent number: RE39299
    Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: September 19, 2006
    Assignees: Eastern Virginia Medical School of the Medical College of Hampton Roads, McGill University
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff-Phail, Lawrence Rosenberg, Jean T. S. Duguid, William P. Duguid
  • High level of expression of INGAP in bacterial and eukaryotic cells
    Patent number: RE39351
    Abstract: Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: October 17, 2006
    Assignee: Eastern Virginia Medical School of the Medical College of Hampton
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff-Phail, Scott W. Barlow