Patents by Inventor Aaron J. Middlebrook

Aaron J. Middlebrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomes and methods of production thereof
    Patent number: 11278495
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: March 22, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Method for liposome preparation by centrifugation
    Patent number: 11191725
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: December 7, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Inverting Device for Liposome Preparation by Centrifugation
    Publication number: 20200330385
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Inverting Device for Liposome Preparation by Centrifugation
    Publication number: 20200330386
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Inverting device for liposome preparation by centrifugation
    Patent number: 10736847
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: August 11, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Inverting Device for Liposome Preparation by Centrifugation
    Publication number: 20200009052
    Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 9, 2020
    Inventors: Oleg Guryev, Aaron J. Middlebrook, Marybeth Sharkey
  • Devices and methods for dissociating a biological tissue sample
    Patent number: 10173220
    Abstract: Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 8, 2019
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Aaron J. Middlebrook, Smita Ghanekar, Brian David Warner, Albert Mach, David Vrane
  • DEVICES AND METHODS FOR DISSOCIATING A BIOLOGICAL TISSUE SAMPLE
    Publication number: 20160069781
    Abstract: Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.
    Type: Application
    Filed: August 4, 2015
    Publication date: March 10, 2016
    Inventors: Aaron J. Middlebrook, Smita Ghanekar, Brian David Warner, Albert Mach, David Vrane