Patents by Inventor Aaron K. Sato

Aaron K. Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110172140
    Abstract: Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
    Type: Application
    Filed: May 26, 2009
    Publication date: July 14, 2011
    Applicant: Dyax Corp.
    Inventors: Arthur C. Ley, Aaron K. Sato, Robert C. Ladner, Mark Stochl
  • Publication number: 20110123532
    Abstract: The present invention provides methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising said molecules. The method includes introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
    Type: Application
    Filed: April 27, 2010
    Publication date: May 26, 2011
    Applicant: OncoMed Pharmaceuticals, Inc.
    Inventors: Austin L. GURNEY, Aaron K. Sato
  • Publication number: 20110070165
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Application
    Filed: September 23, 2010
    Publication date: March 24, 2011
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Patent number: 7910088
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: March 22, 2011
    Assignees: Bracco Suisse SA, Dyax Corp.
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield, Feng Yan
  • Publication number: 20100261875
    Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
    Type: Application
    Filed: January 30, 2008
    Publication date: October 14, 2010
    Applicants: Dyax Corp., Bracco International, B.V.
    Inventors: Daniel T. Dransfield, Aaron K. Sato, Robert Charles Ladner, Regi Thomas
  • Publication number: 20100260672
    Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
    Type: Application
    Filed: December 10, 2009
    Publication date: October 14, 2010
    Applicants: DYAX CORP., BRACCO INTERNATIONAL, B.V.
    Inventors: DANIEL T. DRANSFIELD, AARON K. SATO, ROBERT CHARLES LADNER, REGI THOMAS, PALANIAPPA NANJAPPAN
  • Publication number: 20100003195
    Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides.
    Type: Application
    Filed: June 8, 2009
    Publication date: January 7, 2010
    Inventors: Aaron K. Sato, Daniel J. Sexton, Daniel T. Dransfield, Robert C. Ladner, Christophe Arbogast, Philippe Bussat, Hong Fan, Sudha Khurana, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski
  • Patent number: 7550427
    Abstract: Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: June 23, 2009
    Assignee: Dyax Corp.
    Inventors: Arthur C. Ley, Aaron K Sato, Robert C. Ladner, Mark Stochl
  • Patent number: 7211395
    Abstract: Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin. Preferred serum albumin binding peptides having a high affinity for human serum albumin are particularly disclosed.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: May 1, 2007
    Assignee: Dyax Corp.
    Inventors: Aaron K. Sato, Arthur C. Ley, Edward H. Cohen
  • Patent number: 7041790
    Abstract: Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: May 9, 2006
    Assignee: Dyax Corp.
    Inventors: Charles R. Wescott, Aaron K. Sato
  • Patent number: 6984373
    Abstract: The present invention provides binding moieties for fibrin which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding fibrin and recognizing the form of polymerized fibrin found in thrombi. In addition, the polypeptides have a slow dissociation rate from fibrin, which improves their ability to form a contrast image at the site of a fibrin clot, making the disclosed binding moieties particularly useful as imaging agents for thrombi.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: January 10, 2006
    Assignee: Dyax Corp.
    Inventors: Charles R. Wescott, James P. Beltzer, Aaron K. Sato
  • Publication number: 20040071705
    Abstract: Disclosed is an artificial target-specific ligand that binds to both serum albumin and a particular molecular target. Interaction with serum albumin improves properties when administered to a subject. For example, an interaction between the ligand and serum albumin can extend the half-life of the ligand in circulation.
    Type: Application
    Filed: June 23, 2003
    Publication date: April 15, 2004
    Applicant: DYAX CORPORATION
    Inventors: Aaron K. Sato, Albert Edge
  • Publication number: 20040009534
    Abstract: Disclosed, inter alia, is a method of evaluating a sample that includes a serum protein and one or more one or more compounds physically associated with the serum protein. The method can include using a peptide ligand that specifically interacts with the serum protein to analyze a complex formed by the serum protein and its associated compounds.
    Type: Application
    Filed: June 16, 2003
    Publication date: January 15, 2004
    Applicant: DYAX CORPORATION
    Inventors: Aaron K. Sato, Bruce M. Dawson
  • Publication number: 20030207330
    Abstract: Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.
    Type: Application
    Filed: March 25, 2003
    Publication date: November 6, 2003
    Inventors: Charles R. Wescott, Aaron K. Sato
  • Publication number: 20030143158
    Abstract: The present invention provides binding moieties for fibrin which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding fibrin and recognizing the form of polymerized fibrin found in thrombi. In addition, the polypeptides have a slow dissociation rate from fibrin, which improves their ability to form a contrast image at the site of a fibrin clot, making the disclosed binding moieties particularly useful as imaging agents for thrombi.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 31, 2003
    Inventors: Charles R. Wescott, James P. Beltzer, Aaron K. Sato
  • Publication number: 20030069395
    Abstract: Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin. Preferred serum albumin binding peptides having a high affinity for human serum albumin are particularly disclosed.
    Type: Application
    Filed: March 8, 2002
    Publication date: April 10, 2003
    Inventors: Aaron K. Sato, Arthur C. Ley, Edward H. Cohen