Abstract: This invention relates to recombinant nucleic constructs comprising Type V CRISPR-Cas effector proteins, reverse transcriptases and extended guide nucleic acids and methods of use thereof for modifying nucleic acids in plants.

Abstract: The present invention 10 discloses a game to be played upon a board 12 wherein a plurality of spaces 14 are sequentially placed around the perimeter of the board. The spaces 14 comprise a plurality of property deed spaces with associated property deed cards 20, a plurality of stock certificate spaces with associated stock certificate cards 18, a plurality of option spaces with associated option cards 26, 28, a plurality of collect dividend spaces, a plurality of discounted housing unit spaces and a plurality of draw card spaces having associated therewith draw cards 30. An additional feature of the game may include a set of bond certificates 24 which can be used by each player to provide additional assets for the player to manage and which the player can use for various purposes.