Patents by Inventor Aaron Love

Aaron Love has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220162658
    Abstract: In various aspects and embodiments, the invention provides microbial cells and methods for producing advanced glycosylation products from lower glycosylated intermediates. The microbial cell expresses one or more UDP-dependent glycosyl transferase enzymes in the cytoplasm, for glycosylation of the intermediates. When incubating the microbial strain with a plant extract or fraction thereof comprising the intermediates, these glycosylated intermediates are available for further glycosylation by the cell, and the advanced glycosylation products can be recovered from the media and/or microbial cells.
    Type: Application
    Filed: December 9, 2021
    Publication date: May 26, 2022
    Inventors: Ajikumar Parayil KUMARAN, Christine Nicole S. SANTOS, Jason Eric DONALD, Mary Elizabeth FOWLER, Ryan N. PHILIPPE, Christopher Scott FREI, Aaron LOVE
  • Patent number: 11339412
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: May 24, 2022
    Assignee: Manus Bio Inc.
    Inventors: Ajikumar Parayil Kumaran, Chin-Giaw Lim, Souvik Ghosh, Christopher Pirie, Jason Donald, Aaron Love, Hong Nan, Hsien-Chung Tseng, Christine Nicole S. Santos, Ryan Philippe
  • Publication number: 20220090031
    Abstract: In various aspects, the present invention provides uridine diphosphate-dependent glycosyltransferase (UGT) enzymes capable of catalyzing the transfer of a monosaccharide moiety from a NDP-sugar to the 3? carbon of a sugar moiety of a substrate, such as a terpenoid glycan, thereby functioning as a “1-3 UGT.” In other aspects, the invention provides polynucleotides encoding the 1-3 UGT, and host cells comprising the same. In still other aspects, the invention provides methods for preparing glycosylated substrates, including steviol glycosides, using the enzyme and host cells of this disclosure.
    Type: Application
    Filed: October 6, 2021
    Publication date: March 24, 2022
    Inventors: Jason Eric DONALD, Ajikumar Parayil KUMARAN, Aaron LOVE, Christopher TOOMEY, Christine Nicole S. SANTOS
  • Patent number: 11230724
    Abstract: In various aspects and embodiments, the invention provides microbial cells and methods for producing advanced glycosylation products from lower glycosylated intermediates. The microbial cell expresses one or more UDP-dependent glycosyl transferase enzymes in the cytoplasm, for glycosylation of the intermediates. When incubating the microbial strain with a plant extract or fraction thereof comprising the intermediates, these glycosylated intermediates are available for further glycosylation by the cell, and the advanced glycosylation products can be recovered from the media and/or microbial cells.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: January 25, 2022
    Assignee: MANUS BIO INC.
    Inventors: Ajikumar Parayil Kumaran, Christine Nicole S. Santos, Jason Eric Donald, Mary Elizabeth Fowler, Ryan N. Philippe, Christopher Scott Frei, Aaron Love
  • Patent number: 11168309
    Abstract: In various aspects, the present invention provides uridine diphosphate-dependent glycosyltransferase (UGT) enzymes capable of catalyzing the transfer of a monosaccharide moiety from a NDP-sugar to the 3? carbon of a sugar moiety of a substrate, such as a terpenoid glycan, thereby functioning as a “1-3 UGT.” In other aspects, the invention provides polynucleotides encoding the 1-3 UGT, and host cells comprising the same. In still other aspects, the invention provides methods for preparing glycosylated substrates, including steviol glycosides, using the enzyme and host cells of this disclosure.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: November 9, 2021
    Assignee: MANUS BIO INC.
    Inventors: Jason Eric Donald, Ajikumar Parayil Kumaran, Aaron Love, Christopher Toomey, Christine Nicole S. Santos
  • Publication number: 20210207078
    Abstract: Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a bioreactor medium, the medium comprising an aqueous phase and an extraction phase. The composition of the extraction phase, and the relevant amount with respect to the aqueous phase, enhances production of the secondary metabolite from microbial cells and/or enhances extracellular transfer of the metabolite.
    Type: Application
    Filed: January 19, 2021
    Publication date: July 8, 2021
    Inventors: Aaron LOVE, Adel GHADERI, Jason Eric DONALD, Christine Nicole S. SANTOS, Ajikumar Parayil KUMARAN
  • Publication number: 20210102211
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: October 8, 2020
    Publication date: April 8, 2021
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • Patent number: 10894963
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: January 19, 2021
    Assignee: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • Publication number: 20210009968
    Abstract: In various aspects, the present invention provides uridine diphosphate-dependent glycosyltransferase (UGT) enzymes capable of catalyzing the transfer of a monosaccharide moiety from a NDP-sugar to the 3? carbon of a sugar moiety of a substrate, such as a terpenoid glycan, thereby functioning as a “1-3 UGT.” In other aspects, the invention provides polynucleotides encoding the 1-3 UGT, and host cells comprising the same. In still other aspects, the invention provides methods for preparing glycosylated substrates, including steviol glycosides, using the enzyme and host cells of this disclosure.
    Type: Application
    Filed: June 25, 2020
    Publication date: January 14, 2021
    Inventors: Jason Eric DONALD, Ajikumar Parayil KUMARAN, Aaron LOVE, Christopher TOOMEY, Christine Nicole S. SANTOS
  • Patent number: 10837018
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 17, 2020
    Assignee: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • Publication number: 20200299735
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Inventors: Ajikumar Parayil KUMARAN, Chin-Giaw LIM, Souvik GHOSH, Christopher PIRIE, Jason DONALD, Aaron LOVE, Hong NAN, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Patent number: 10662442
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: May 26, 2020
    Assignee: MANUS BIO INC.
    Inventors: Ajikumar Parayil Kumaran, Chin-Giaw Lim, Souvik Ghosh, Christopher Pirie, Jason Donald, Aaron Love, Hong Nan, Hsien-Chung Tseng, Christine Nicole S. Santos, Ryan Philippe
  • Publication number: 20200087692
    Abstract: In various aspects and embodiments, the invention provides microbial cells and methods for producing advanced glycosylation products from lower glycosylated intermediates. The microbial cell expresses one or more UDP-dependent glycosyl transferase enzymes in the cytoplasm, for glycosylation of the intermediates. When incubating the microbial strain with a plant extract or fraction thereof comprising the intermediates, these glycosylated intermediates are available for further glycosylation by the cell, and the advanced glycosylation products can be recovered from the media and/or microbial cells.
    Type: Application
    Filed: July 16, 2019
    Publication date: March 19, 2020
    Inventors: Ajikumar Parayil KUMARAN, Christine Nicole S. SANTOS, Jason Eric DONALD, Mary Elizabeth FOWLER, Ryan N. PHILIPPE, Christopher Scott FREI, Aaron LOVE
  • Publication number: 20180320184
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 8, 2018
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • Publication number: 20180245103
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 30, 2018
    Inventors: Ajikumar Parayil KUMARAN, Chin-Giaw LIM, Souvik GHOSH, Christopher PIRIE, Jason DONALD, Aaron LOVE, Hong NAN, Hsien-Chung TSENG, Christine Nicole S. SANTOS, Ryan PHILIPPE
  • Publication number: 20160186178
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: July 25, 2014
    Publication date: June 30, 2016
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov