Patents by Inventor Aaron M. Fleming

Aaron M. Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of nucleic acid lesions and adducts using nanopores
    Patent number: 9429561
    Abstract: Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: August 30, 2016
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Cynthia J. Burrows, Henry S. White, Ryuji Kawano, Aaron M. Fleming, Na An
  • DETECTION OF NUCLEIC ACID LESIONS AND ADDUCTS USING NANOPORES
    Publication number: 20150185200
    Abstract: Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
    Type: Application
    Filed: March 13, 2015
    Publication date: July 2, 2015
    Inventors: Cynthia J. Burrows, Henry S. White, Ryuji Kawano, Aaron M. Fleming, Na An
  • Detection of nucleic acid lesions and adducts using nanopores
    Patent number: 9005425
    Abstract: Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: April 14, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Cynthia J. Burrows, Henry S. White, Ryuji Kawano, Aaron M. Fleming, Na An
  • DETECTION OF NUCLEIC ACID LESIONS AND ADDUCTS USING NANOPORES
    Publication number: 20120091005
    Abstract: Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
    Type: Application
    Filed: September 7, 2011
    Publication date: April 19, 2012
    Inventors: Cynthia J. Burrows, Henry S. White, Ryuji Kawano, Aaron M. Fleming, Na An