Patents by Inventor Aaron MICHELS

Aaron MICHELS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AIRBORNE AND/OR SPACEBORNE OPTICAL FLOOD AND FLOOD DAMAGE SENSORY SYSTEM AND METHOD THEREOF
    Publication number: 20230401651
    Abstract: The invention relates to automated airborne and/or spaceborne optical flood sensory and flood impact sensory method and system for measuring and/or forecasting a weightage-specific, quantitative flooding measure value and/or a weightage-specific, quantified flooding impact extent measure value, the weightage being based on an object density of a selected topographic and/or geographic area impacted by an occurrence of a flood event.
    Type: Application
    Filed: August 25, 2023
    Publication date: December 14, 2023
    Applicant: Swiss Reinsurance Company Ltd.
    Inventors: Lukas SUNDERMANN, Vipin Kozhikkoottingal SREENIVASAN, Aaron MICHEL, Carl BERNIER
  • Insulin mimotopes and methods of using the same
    Patent number: 11602556
    Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: March 14, 2023
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Aaron Michels, Peter A. Gottlieb
  • Compounds and methods for treating autoimmunity
    Patent number: 11052060
    Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: July 6, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
    Inventors: Steve Orndorff, Aaron Michels
  • Administration of oral methyldopa
    Patent number: 11013707
    Abstract: Methods of administering methyldopa to a subject in a fasting state to increase bioavailability of the methyldopa.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 25, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
    Inventors: Steve Orndorff, Aaron Michels
  • Insulin Mimotopes and Methods of Using the Same
    Publication number: 20190321448
    Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 24, 2019
    Inventors: Aaron Michels, Peter A. Gottlieb
  • ADMINISTRATION OF ORAL METHYLDOPA
    Publication number: 20190290607
    Abstract: Methods of administering methyldopa to a subject in a fasting state to increase bioavailability of the methyldopa.
    Type: Application
    Filed: March 23, 2018
    Publication date: September 26, 2019
    Inventors: Steve Orndorff, Aaron Michels
  • COMPOUNDS AND METHODS FOR TREATING AUTOIMMUNITY
    Publication number: 20190262301
    Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
    Type: Application
    Filed: March 19, 2019
    Publication date: August 29, 2019
    Inventors: Steve Orndorff, Aaron Michels
  • Insulin mimotopes and methods of using the same
    Patent number: 10363288
    Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: July 30, 2019
    Assignees: National Jewish Health, The Regents of the University of Colorado, a body corporate
    Inventors: Aaron Michels, John Kappler, Peter A. Gottlieb
  • NOVEL MULTIPLEX ASSAYS TO DIAGNOSE OR EVALUATE DISEASES OR DISORDERS IN MAMMALS
    Publication number: 20180335431
    Abstract: The invention includes methods and kits that can be used to simultaneously determine whether an antibody out of a plurality of antibodies is present in a sample. In certain embodiments, at least one of the antibodies comprises an autoantibody. In other embodiments, the methods and kits of the invention can be used to simultaneously determine if a subject is likely to develop or has developed each one of a plurality of diseases or disorders.
    Type: Application
    Filed: November 17, 2016
    Publication date: November 22, 2018
    Inventors: LIPING YU, MARIAN REWERS, AARON MICHELS
  • METHODS OF PREVENTING AND TREATING AUTOIMMUNITY
    Publication number: 20180116988
    Abstract: Methods of preventing, treating or ameliorating autoimmune diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of methyldopa. Pharmaceutical compositions containing therapeutically effective amounts of methyldopa in extended release formulations and methods of using the same are also provided.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 3, 2018
    Inventors: Thomas J. ANCHORDOQUY, Peter A. GOTTLIEB, Aaron MICHELS, David OSTROV
  • INSULIN MIMOTOPES AND METHODS OF USING THE SAME
    Publication number: 20180117124
    Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 3, 2018
    Inventors: Aaron MICHELS, John KAPPLER, Peter A. GOTTLIEB
  • Methods of treating autoimmunity
    Patent number: 9820957
    Abstract: Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-?-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of D-?-methyldopa.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: November 21, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Steve Orndorff, Aaron Michels, Peter Gottlieb
  • METHODS OF TREATING AUTOIMMUNITY
    Publication number: 20170273927
    Abstract: Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-?-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of D-?-methyldopa.
    Type: Application
    Filed: March 22, 2017
    Publication date: September 28, 2017
    Inventors: Steve Orndorff, Aaron Michels, Peter Gottlieb
  • Compounds that modulate autoimmunity and methods of using the same
    Patent number: 9629848
    Abstract: The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: April 25, 2017
    Assignees: The Regents of the University of Colorado, a body corporate, The University of Florida Research Foundation Incorporated
    Inventors: Aaron Michels, Maki Nakayama, David Ostrov
  • COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME
    Publication number: 20150038480
    Abstract: The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
    Type: Application
    Filed: May 29, 2012
    Publication date: February 5, 2015
    Applicants: UNIVERSITY OF FLORIDA RESERCH FOUNDATION INCORPORTED, THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate
    Inventors: Aaron Michels, Maki Nakayama, David Ostrov
  • COMPOSITIONS, METHODS AND USES FOR TREATMENT OF TYPE 1 DIABETES
    Publication number: 20120225813
    Abstract: Embodiments herein concern compositions and methods for treating diabetes in a subject.
    Type: Application
    Filed: June 13, 2011
    Publication date: September 6, 2012
    Inventors: Eli C. LEWIS, Peter GOTTLIEB, Charles A. DINARELLO, Leland SHAPIRO, Aaron MICHELS
  • COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME
    Publication number: 20120195929
    Abstract: The invention provides methods of preventing, treating or ameliorating autoimmune diseases such as diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
    Type: Application
    Filed: June 4, 2010
    Publication date: August 2, 2012
    Inventors: George Eisenbarth, Aaron Michels, David Ostrov, Maki Nakayama
  • COMPOSITIONS, METHODS AND USES FOR TREATING DIABETES
    Publication number: 20110112017
    Abstract: Embodiments herein concern compositions and methods for treating diabetes in a subject.
    Type: Application
    Filed: June 11, 2010
    Publication date: May 12, 2011
    Inventors: Lee SHAPIRO, Charles A. DINARELLO, Eli LEWIS, Peter GOTTLIEB, Amy WALLACE, Aaron MICHELS, Gregory B. POTTS