Patents by Inventor Aaron Muth

Aaron Muth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20220089549
    Abstract: The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.
    Type: Application
    Filed: November 5, 2021
    Publication date: March 24, 2022
    Inventors: Paul R. Thompson, Aaron Muth, Venkataraman Subramanian
  • Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof
    Patent number: 11208386
    Abstract: The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: December 28, 2021
    Assignee: University of Massachusetts
    Inventors: Paul R. Thompson, Aaron Muth, Venkataraman Subramanian
  • INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20200339518
    Abstract: The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.
    Type: Application
    Filed: November 27, 2017
    Publication date: October 29, 2020
    Inventors: Paul R. Thompson, Aaron Muth, Venkataraman Subramanian
  • Polyamine transport selective therapeutic agents with enhanced stability
    Patent number: 9926260
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: March 27, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • POLYAMINE TRANSPORT SELECTIVE THERAPEUTIC AGENTS WITH ENHANCED STABILITY
    Publication number: 20160311756
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Application
    Filed: April 26, 2016
    Publication date: October 27, 2016
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Polyamine transport selective therapeutic agents with enhanced stability
    Patent number: 9346741
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 24, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Anti-metastatic agents predicated upon polyamine macrocyclic conjugates
    Patent number: 9266815
    Abstract: Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s).
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 23, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE MACROCYCLIC CONJUGATES
    Publication number: 20150057361
    Abstract: Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s).
    Type: Application
    Filed: March 13, 2013
    Publication date: February 26, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • POLYAMINE TRANSPORT SELECTIVE THERAPEUTIC AGENTS WITH ENHANCED STABILITY
    Publication number: 20150017231
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 15, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Anti-metastatic agents predicated upon polyamine macrocylic conjugates
    Patent number: RE47750
    Abstract: Disclosed herein are novel motuporamine compounds that act as anti-metastatic agents with low toxicity and high anti-migration activity. The non-toxic, anti-metastatic agents may be given to patients with potential or actual metastatic cancers, such as pancreatic cancers, alone in combination with known and/or new therapies to help block the growth and spread of tumor(s).
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: December 3, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth