Patents by Inventor Aaron O. BAILEY

Aaron O. BAILEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectrometry analysis of biomolecules by multiple charge state selection using a concurrent precursor isolation technique
    Patent number: 9899204
    Abstract: A method is described for the analysis of biological polymers, for example, intact proteins or oligonucleotides, by mass spectrometry. This method produces sample ions from a sample containing biological polymers, and ion species are selected that correspond to different charge states of a biological polymer molecule. The ion species are concurrently isolated from the sample ions to generate precursor ions in an ion trap mass spectrometer or in a quadrupole mass filter mass spectrometer. Precursor ions or product ions derived from the precursor ions may then be mass analyzed. The mass analysis step may include fragmenting the precursor ions to form product ions.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 20, 2018
    Assignee: Thermo Finnigan LLC
    Inventor: Aaron O. Bailey
  • Systems and methods for targeted top down discovery
    Patent number: 9847216
    Abstract: A system for analyzing a sample includes a chromatographic device, a mass resolving device, and a data processor. The chromatographic device is configured to separate components of the sample using a chromatographic column. The mass resolving device is configured to characterize mass spectrographic properties of the separated components in an intact state, and fragment the separated components and characterize mass spectrographic properties of the resulting fragments.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: December 19, 2017
    Assignee: Thermo Finnigan LLC
    Inventors: Aaron O. Bailey, Paul R. Gazis, David M. Horn
  • MASS SPECTROMETRY ANALYSIS OF BIOMOLECULES BY MULTIPLE CHARGE STATE SELECTION USING A CONCURRENT PRECURSOR ISOLATION TECHNIQUE
    Publication number: 20170352529
    Abstract: A method is described for the analysis of biological polymers, for example, intact proteins or oligonucleotides, by mass spectrometry. This method produces sample ions from a sample containing biological polymers, and ion species are selected that correspond to different charge states of a biological polymer molecule. The ion species are concurrently isolated from the sample ions to generate precursor ions in an ion trap mass spectrometer or in a quadrupole mass filter mass spectrometer. Precursor ions or product ions derived from the precursor ions may then be mass analyzed. The mass analysis step may include fragmenting the precursor ions to form product ions.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventor: Aaron O. BAILEY
  • Systems and Methods for Targeted Top Down Discovery
    Publication number: 20170047209
    Abstract: A system for analyzing a sample includes a chromatographic device, a mass resolving device, and a data processor. The chromatographic device is configured to separate components of the sample using a chromatographic column. The mass resolving device is configured to characterize mass spectrographic properties of the separated components in an intact state, and fragment the separated components and characterize mass spectrographic properties of the resulting fragments.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 16, 2017
    Inventors: Aaron O. BAILEY, Paul R. GAZIS, David M. HORN