Abstract: A gyroscopic roll stabilizer includes an enclosure, a flywheel assembly, a bearing, a motor, and a bearing cooling circuit. The enclosure is mounted to a gimbal for rotation about a gimbal axis and configured to maintain a below-ambient pressure. The flywheel assembly includes a flywheel and flywheel shaft. The bearing rotatably mounts the flywheel assembly inside the enclosure for rotation about a flywheel axis. The bearing has an inner race and an outer race. The inner race is rotationally fixed relative to the flywheel shaft, and the outer race is held rotationally fixed relative to the enclosure. The motor is operative to rotate the flywheel assembly. The bearing cooling circuit is configured to transfer heat away from the bearing by recirculating coolant along a closed fluid pathway. The gyroscopic roll stabilizer is configured to transfer heat away from the inner and/or outer race of the bearing to the coolant.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The augments, systems and methods for supporting acetabular implants described herein can include an augment (100) for supporting an acetabular shell (90) having a first portion (136) of a locking mechanism. The system can also include a shell having a second portion of a locking mechanism (96). The first portion of the locking mechanism and the second portion of the locking mechanism can be adapted to move relative to one another from an unlocked state to a locked state to fixedly couple the augment to the shell. In some examples, the augment can be contourable to match the shape of a bone.

Abstract: A method of making a custom acetabular implant for a patient. The method comprises acquiring and analyzing tomography data of the patient, and obtaining geometry and measurement parameters of the patient's pelvic anatomy. A standard acetabular prosthesis blank is selected from a plurality of pre-manufactured blanks, and includes a cup portion and at least one flange. The method includes shaping the blank acetabular prosthesis using a custom deforming fixture such that the shaped acetabular prosthesis has a final shaped geometry and measurement parameters to substantially match the patient's pelvic anatomy relative to the patient's acetabulum.

Abstract: An acetabular prosthesis is described that includes a shell having an outer surface and an inner surface, the outer surface defining an external shape. There is at least one through bore extending from the outer surface of the shell to the inner surface of the shell. At least one augment is configured to be positioned at least partially within the at least one through bore of the shell such that, in an assembled state, the shell and the at least one augment define a modified external shape.

Abstract: A method of anatomically positioning screw holes in an acetabular implant that can be used in surgery, such as a total hip arthroplasty. In some examples the method can be used to position holes in a shell of the implant. The method can include, for example, obtaining anatomic data including data defining an arch of bone behind an acetabulum of the living being, the arch of bone extending from a superior anterior portion to an inferior posterior portion of the acetabulum. The method can further include positioning a first series of holes along a first arched line within the acetabular shell, the first arched line determined based on the anatomic data for the arch of bone proximate the acetabulum of the living being.

Abstract: The augments, systems and methods for supporting acetabular implants described herein can include an augment (100) for supporting an acetabular shell (90) having a first portion (136) of a locking mechanism. The system can also include a shell having a second portion of a locking mechanism (96). The first portion of the locking mechanism and the second portion of the locking mechanism can be adapted to move relative to one another from an unlocked state to a locked state to fixedly couple the augment to the shell. In some examples, the augment can be contourable to match the shape of a bone.

Abstract: An acetabular prosthesis is described that includes a shell having an outer surface and an inner surface, the outer surface defining an external shape. There is at least one through bore extending from the outer surface of the shell to the inner surface of the shell. At least one augment is configured to be positioned at least partially within the at least one through bore of the shell such that, in an assembled state, the shell and the at least one augment define a modified external shape.

Abstract: An implant for a hip can include a lateral augment adapted to be coupled to a lateral side of a femoral body implant. The lateral augment can include a body portion having a first surface, a second surface opposite the first surface, and a protrusion extending from the second surface. The protrusion can have a shape adapted to mate with a complementary shaped recess formed in the lateral side of the femoral body implant. An aperture can be positioned in the body portion and extend through the protrusion. A fastener can be received through the aperture and adapted to be threadably secured to the lateral bore. The fastener can be configured to have a length sufficient to pass through a portion of a greater trochanter for securing the portion of the greater trochanter and the lateral augment to the femoral body implant.

Abstract: A bone preparation system, such as a broach, includes at least a first member and a second member. The first member and the second member may be connected. Both the first member and the second member, when attached to the first member, are configured to directly contact and broach an anatomy.

Abstract: An acetabular prosthesis is described that includes a shell having an outer surface and an inner surface, the outer surface defining an external shape. There is at least one through bore extending from the outer surface of the shell to the inner surface of the shell. At least one augment is configured to be positioned at least partially within the at least one through bore of the shell such that, in an assembled state, the shell and the at least one augment define a modified external shape.

Abstract: A method of anatomically positioning screw holes in an acetabular implant that can be used in surgery, such as a total hip arthroplasty. In some examples the method can be used to position holes in a shell of the implant. The method can include, for example, obtaining anatomic data including data defining an arch of bone behind an acetabulum of the living being, the arch of bone extending from a superior anterior portion to an inferior posterior portion of the acetabulum. The method can further include positioning a first series of holes along a first arched line within the acetabular shell, the first arched line determined based on the anatomic data for the arch of bone proximate the acetabulum of the living being.

Abstract: Apparatus and methods of protecting modular implant connection portions are provided. A guard includes an outer sidewall and an inner sidewall defining a cavity that covers a modular implant connection portion. The modular implant connection covered with the guard can facilitate test-fitting of other modular implant components and allows reaming of the tissue around the guard.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: Apparatus and methods of protecting modular implant connection portions are provided. A guard includes an outer sidewall and an inner sidewall defining a cavity that covers a modular implant connection portion. The modular implant connection covered with the guard can facilitate test-fitting of other modular implant components and allows reaming of the tissue around the guard.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: A prosthesis according to the present disclosure includes a shell. A liner is disposed within the shell, and a femoral head may be disposed within the liner. A locking mechanism may assist in securing the liner within the shell. The locking mechanism may be removed when the shell, liner, and femoral head are implanted. The shell extends beyond a hemisphere of the shell, and the liner extends beyond a hemisphere of the liner.

Abstract: An orthopedic device includes a monolithic patient-specific guide. The patient-specific guide includes a three-dimensional contact surface preoperatively configured from medical scans of a specific patient as a negative surface of a medial portion of a proximal femoral bone of the patient according to a preoperative surgical plan for the patient. The guide also includes a proximal planar surface configured for guiding a resection of a femoral neck of the patient, and a scale formed on the planar surface. The scale is configured for indicating a preoperatively planned femoral version of a femoral stem implant and deviations therefrom.

Abstract: A method for preparing a bone of a joint of a patient includes mounting a patient-specific reference guide on a bone of a joint of a patient. A connecting portion of the reference guide is coupled to a miniaturized numerically controlled instrument having a housing including a controller, a processor and a tool driver. The patient-specific reference guide has a three-dimensional inner surface preoperatively configured to mirror and mate with a corresponding surface of a bone of a joint of a patient in only one position. The patient-specific reference guide is configured to automatically register the numerically controlled instrument to the patient's bone portion intraoperatively. The cutting tool is guided by the controlled with signals from the processor along a patient-specific tool path determined during the preoperative plan for preparing a portion of the bone.

Abstract: Disclosed is a modular trial system to select a neck length. The system may be in a hexagonal or click embodiments. A neck member may having at least a locating step with a locating step face. A head member may have at least a first groove and a second groove in an internal bore. The head member may be rotated relative to the neck member to select various trial lengths of the neck.