Abstract: Systems and methods are provided for determining an implantation curve or path, along which an implant such as a nail or a screw may be inserted and implanted into a bone, and/or to determine an entry point, which is the point at which the surgeon opens the bone for inserting the implant. According to the invention, a 2D X-ray image is received, which X-ray image shows a surgical region of interest. In that X-ray image, a first point associated with a structure of interest as well as an implantation path within the bone for an implant intended to be implanted may be determined. An entry point for an insertion of the implant into the bone is located on the implantation path. It is noted that the first point may not be the entry point.