Patents by Inventor Aaron R Goerke

Aaron R Goerke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PURIFICATION OF NATIVE OR MUTANT FORMS OF DIPHTHERIA TOXIN
    Publication number: 20140193876
    Abstract: The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and DNA. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of diphtheria toxin suitable for in vitro and in vivo applications.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 10, 2014
    Inventors: Aaron R. Goerke, Thomas Svab, Patrick McHugh, Kristin Valente
  • Cell-free synthesis of proteins containing unnatural amino acids
    Patent number: 8715958
    Abstract: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of polypeptides containing unnatural amino acids at one or more specified residues of the polypeptide.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: May 6, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron R. Goerke, James Robert Swartz
  • CELL-FREE SYNTHESIS OF PROTEINS CONTAINING UNNATURAL AMINO ACIDS
    Publication number: 20100093024
    Abstract: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of polypeptides containing unnatural amino acids at one or more specified residues of the polypeptide.
    Type: Application
    Filed: June 29, 2007
    Publication date: April 15, 2010
    Inventors: Aaron R. Goerke, James Robert Swartz
  • Methods of adenovirus purification
    Patent number: 7326555
    Abstract: A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of host cell contaminants away from the virus, depth filtration or centrifugation, ultrafiltration, nuclease digestion and chromatography to robustly and economically produce highly purified product. This process results in contaminating DNA levels which are consistently below detectable levels.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: February 5, 2008
    Assignee: Merck & Co., Inc.
    Inventors: John O. Konz, Jr., Ann L. Lee, Chi Shung Brian To, Aaron R Goerke