Abstract: Teeth can be hardened and made more resistant to acid damage if treated with compositions that allow for the remineralization and demineralization of minerals found in teeth. Exchanging ions in hydroxyapatite for fluoride or other metal ions can result in teeth that are more resistant to chemical and physical insults.

Abstract: Teeth can be hardened and made more resistant to acid damage if treated with compositions that allow for the remineralization and demineralization of minerals found in teeth. Exchanging ions in hydroxyapatite for fluoride or other metal ions can result in teeth that are more resistant to chemical and physical insults.

Abstract: Disclosed are oral hygiene regimens comprising a plurality of steps involving the use of two or more oral care products containing actives effective to provide one or more benefits including cleaning, antimicrobial, antiplaque, anticaries, anti-calculus, anti-demineralizing, anti-erosion, antisensitivity/desensitizing, whitening, surface conditioning, polishing, and pH-balancing, wherein the plurality of steps are conducted and sequenced for maximizing delivery of oral care actives to target surfaces of a subject's oral cavity thereby achieving optimum oral health and hygiene benefits. In one aspect, a regimen comprises at least once daily of each of the following steps: (a) applying an antimicrobial dentifrice to oral cavity surfaces, and (b) rinsing the oral cavity with an antimicrobial mouthrinse, wherein at least one of steps (a) and (b) is conducted prior to retiring at night.

Abstract: A method of conducting clinical trials to evaluate the efficacy of agents or methods of caries prevention and treatment comprising the steps of conducting a visual-tactile assessment on qualifying human subjects of moderate to high caries incidence populations, assigning subjects to control group(s) and experimental group(s), supervising tooth brushing one or more times per day for a period of about 8 to about 12 months which runs concurrently with the school year and thereafter evaluating the efficacy of the product.