Patents by Inventor Aaron Ross Cooper

Aaron Ross Cooper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DESIGNING HIGHLY REGULATED LENTIVIRAL VECTORS POSSESING STRICT ENDOGENOUS REGULATION
    Publication number: 20240082427
    Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).
    Type: Application
    Filed: January 28, 2022
    Publication date: March 14, 2024
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis, Richard A. Morgan, Aaron Ross Cooper
  • TRANSCRIPTIONAL RELAY SYSTEM
    Publication number: 20220177897
    Abstract: Described herein are transcriptional relay systems useful for reducing background signal in protein expression and reporter assays. These systems utilize a nucleic acid system wherein a promoter sequence controls expression of a synthetic transcription factor that activates transcription of a reporter molecule.
    Type: Application
    Filed: November 22, 2021
    Publication date: June 9, 2022
    Inventors: Leon Yen-Lee CHAN, Aaron Ross COOPER, Henry CHAN
  • SYSTEMS FOR PROTEIN-PROTEIN INTERACTION SCREENING
    Publication number: 20220162667
    Abstract: Described herein are methods and systems useful for interrogating protein-protein interactions. These systems utilize non-functional fragments of polypeptides that can complement each other to form a fully functional fragment in vivo. The fully functional polypeptide releases a transcription regulating polypeptide that can bind and activate or repress a reporter element.
    Type: Application
    Filed: December 6, 2019
    Publication date: May 26, 2022
    Inventors: Henry CHAN, Leon Yen-Lee CHAN, Aaron Ross COOPER
  • OPTIMIZED LENTIVIRAL VECTOR COMPROMISING MINIMAL ENHANCER ELEMENTS FOR STEM CELL GENE THERAPY OF HEMOGLOBINOPATHIES
    Publication number: 20220136007
    Abstract: In certain embodiments a lentiviral vector having optimized reduced size LCR with improved enhancer activity is provided. In certain embodiments direct treatment of a subject by direct introduction of the vector(s) described herein is contemplated. The lentiviral compositions may be formulated for delivery by any available route including, but not limited to parenteral (e.g., intravenous), intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, rectal, and vaginal.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 5, 2022
    Inventors: Donald B. Kohn, Roger Paul Hollis, Richard A. Morgan, Aaron Ross Cooper
  • RETROVIRAL VECTORS CONTAINING A REVERSE ORIENTATION HUMAN UBIQUITIN C PROMOTER
    Publication number: 20180185415
    Abstract: In certain embodiments a recombinant retroviral vector is provided where the vector comprises a human ubiquitin C (UBC) promoter operably linked to a transgene where the promoter and the transgene are in a reverse orientation so that the direction of transcription of the transgene from the promoter is oriented towards a 5? long terminal repeat (LTR) of the vector.
    Type: Application
    Filed: June 22, 2016
    Publication date: July 5, 2018
    Inventors: Donald B. Kohn, Aaron Ross Cooper