Patents by Inventor Aaron Rulison
Aaron Rulison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11693182Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: GrantFiled: July 10, 2020Date of Patent: July 4, 2023Assignee: Pacific Biosciences of California, Inc.Inventors: Shang Wang, Mathieu Foquet, Paul Lundquist, Aaron Rulison, Mark McDonald, Ariel Herrmann
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Publication number: 20230112975Abstract: Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system. Waveguides in optical analytical systems can exhibit variable and increasing back reflection of single-wavelength illumination over time, thus limiting their effectiveness and reliability. The systems are also subject to optical interference under conditions that have been used to overcome the back reflection. Novel systems and approaches using broadband illumination light with multiple longitudinal modes have been developed to improve optical transmission and analysis in these systems. Novel systems and approaches for the alignment of a target waveguide device and an optical source are also disclosed.Type: ApplicationFiled: August 15, 2022Publication date: April 13, 2023Applicant: Pacific Biosciences of California, Inc.Inventors: Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Russell BERMAN
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Patent number: 11415745Abstract: Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system. Waveguides in optical analytical systems can exhibit variable and increasing back reflection of single-wavelength illumination over time, thus limiting their effectiveness and reliability. The systems are also subject to optical interference under conditions that have been used to overcome the back reflection. Novel systems and approaches using broadband illumination light with multiple longitudinal modes have been developed to improve optical transmission and analysis in these systems. Novel systems and approaches for the alignment of a target waveguide device and an optical source are also disclosed.Type: GrantFiled: March 15, 2021Date of Patent: August 16, 2022Assignee: Pacific Biosciences of California, Inc.Inventors: Alexey Kuritsyn, Mark Mcdonald, Aaron Rulison, Russell Berman
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Patent number: 11269199Abstract: We describe methods of producing gratings such as Bragg gratings with optical waveguides. Described are the writing and erasing of gratings within SiON waveguides by forming standing waves. Methods, systems, instruments, and devices are described that provide improved transmission of light through such waveguides.Type: GrantFiled: April 11, 2019Date of Patent: March 8, 2022Assignee: Pacific Biosciences of California, Inc.Inventors: Mark McDonald, Aaron Rulison, Paul Lundquist, Tsuei-Lian Wang, Deborah Pao-Tung Kwo, Shang Wang
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Patent number: 11162910Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.Type: GrantFiled: June 27, 2016Date of Patent: November 2, 2021Assignees: CALIPER LIFE SCIENCES, INC., Canon U.S.A., Inc.Inventors: Steven A. Sundberg, Michael R. Knapp, Ivor T. Knight, Deborah J. Boles, Aaron Rulison, Wesley B. Dong, Andrew Fabans, Edward Donlon, Robert Moti, Michael Slater
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Publication number: 20210311254Abstract: Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system. Waveguides in optical analytical systems can exhibit variable and increasing back reflection of single-wavelength illumination over time, thus limiting their effectiveness and reliability. The systems are also subject to optical interference under conditions that have been used to overcome the back reflection. Novel systems and approaches using broadband illumination light with multiple longitudinal modes have been developed to improve optical transmission and analysis in these systems. Novel systems and approaches for the alignment of a target waveguide device and an optical source are also disclosed.Type: ApplicationFiled: March 15, 2021Publication date: October 7, 2021Applicant: Pacific Biosciences of California, Inc.Inventors: Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Russell BERMAN
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Publication number: 20210285881Abstract: Provided herein are highly multiplexed optical analytical systems for improved nucleic acid sequencing. The systems include a plurality of highly multiplexed optical chips, at least one optical source, and a plurality of optical delivery devices for illuminating an array of nanoscale rection regions on each of the optical chips. In use, the reaction regions contain fluorescent nucleic acid sequencing reagents and are arranged to report nucleic acid sequence information to optical detectors associated with the multiplexed optical chips in real time. The systems enable a massive increase in the scale of nucleic acid sequencing reactions capable of being performed within a single instrument without a corresponding increase in size, complexity, or cost of the instrument.Type: ApplicationFiled: February 18, 2021Publication date: September 16, 2021Inventors: Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Annette GROT
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Publication number: 20210215607Abstract: Provided herein are cartridges, packaged devices, and systems for improved nucleic acid sequencing. The cartridges, devices, and systems include a highly multiplexed optical chip comprising a plurality of nanoscale reaction regions that is configured to perform and report nucleic acid sequencing reactions. The chips are, in some embodiments, packaged for use in analytical nucleic acid sequencing reactions. The chips may be attached to a printed circuit board, may be surrounded by a protective enclosure, may include a flow cell, and may include optical features to minimize or block photobleaching of the sequencing reagents and background fluorescent signals. Also provided are analytical systems for nucleic acid sequencing that comprise the disclosed cartridges and packaged devices.Type: ApplicationFiled: January 14, 2021Publication date: July 15, 2021Applicant: Pacific Biosciences of California, Inc.Inventors: Russell BERMAN, Jaime Juan BENITEZ-MARZAN, Natasha POPOVICH, Aaron RULISON, Ravi SAXENA
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Patent number: 11054576Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: GrantFiled: July 18, 2019Date of Patent: July 6, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Shang Wang, Mathieu Foquet, Paul Lundquist, Aaron Rulison, Mark McDonald, Ariel Herrmann
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Patent number: 10948652Abstract: Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system. Waveguides in optical analytical systems can exhibit variable and increasing back reflection of single-wavelength illumination over time, thus limiting their effectiveness and reliability. The systems are also subject to optical interference under conditions that have been used to overcome the back reflection. Novel systems and approaches using broadband illumination light with multiple longitudinal modes have been developed to improve optical transmission and analysis in these systems. Novel systems and approaches for the alignment of a target waveguide device and an optical source are also disclosed.Type: GrantFiled: November 3, 2018Date of Patent: March 16, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Alexey Kuritsyn, Mark McDonald, Aaron Rulison, Russell Berman
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Publication number: 20210033788Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: ApplicationFiled: July 10, 2020Publication date: February 4, 2021Applicant: Pacific Biosciences of California, Inc.Inventors: Shang WANG, Mathieu FOQUET, Paul LUNDQUIST, Aaron RULISON, Mark MCDONALD, Ariel HERRMANN
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Patent number: 10871460Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.Type: GrantFiled: May 25, 2018Date of Patent: December 22, 2020Assignee: Canon U.S.A., Inc.Inventors: Ivor T. Knight, Deborah John Boles, Aaron Rulison, Wesley B. Dong, Andrew Fabans, Allen Boronkay, Edward Donlon, Robert Moti, Michael Slater, Steven A. Sundberg, Michael R. Knapp
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Publication number: 20200049882Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: ApplicationFiled: July 18, 2019Publication date: February 13, 2020Applicant: Pacific Biosciences of California, Inc.Inventors: Shang WANG, Mathieu FOQUET, Paul LUNDQUIST, Aaron RULISON, Mark MCDONALD, Ariel HERRMANN
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Patent number: 10487356Abstract: Optical delivery devices and integrated analytical systems comprising the optical delivery devices are provided. The optical delivery devices include optical inputs, optical outputs, and integrated optical waveguides that are configured for coupling of optical energy to a target waveguide device through free space. The integrated analytical systems include the optical delivery devices in combination with the target waveguide device. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: GrantFiled: March 16, 2016Date of Patent: November 26, 2019Assignee: Pacific Biosciences of California, Inc.Inventors: Paul Lundquist, Mark McDonald, Aaron Rulison
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Publication number: 20190317340Abstract: We describe methods of producing gratings such as Bragg gratings with optical waveguides. Described are the writing and erasing of gratings within SiON waveguides by forming standing waves. Methods, systems, instruments, and devices are described that provide improved transmission of light through such waveguides.Type: ApplicationFiled: April 11, 2019Publication date: October 17, 2019Inventors: Mark McDonald, Aaron Rulison, Paul Lundquist, Tsuei-Lian Wang, Deborah Pao-Tung Kwo, Shang Wang
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Patent number: 10365434Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.Type: GrantFiled: June 11, 2016Date of Patent: July 30, 2019Assignee: Pacific Biosciences of California, Inc.Inventors: Shang Wang, Mathieu Foquet, Paul Lundquist, Aaron Rulison, Mark McDonald, Ariel Herrmann
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Publication number: 20190179078Abstract: Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system. Waveguides in optical analytical systems can exhibit variable and increasing back reflection of single-wavelength illumination over time, thus limiting their effectiveness and reliability. The systems are also subject to optical interference under conditions that have been used to overcome the back reflection. Novel systems and approaches using broadband illumination light with multiple longitudinal modes have been developed to improve optical transmission and analysis in these systems. Novel systems and approaches for the alignment of a target waveguide device and an optical source are also disclosed.Type: ApplicationFiled: November 3, 2018Publication date: June 13, 2019Inventors: Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Russell BERMAN
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Patent number: 10302972Abstract: We have seen that some waveguides exhibit variable and increasing back reflection of single wavelength illumination over time, limiting their effectiveness and reliability. We have developed approaches to improve the transmission of these waveguides. We have found that by modulating the illumination wavelength over a small wavelength range we can reduce or eliminate this back reflection from the waveguide. In addition, we describe the writing and erasing of gratings within SiON waveguides by forming standing waves. Methods, systems, instruments, and devices are described that provide improved transmission of light through such waveguides.Type: GrantFiled: January 21, 2016Date of Patent: May 28, 2019Assignee: Pacific Biosciences of California, Inc.Inventors: Mark McDonald, Aaron Rulison, Paul Lundquist, Tsuei-Lian Wang, Deborah Pao-Tung Kwo, Shang Wang
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Publication number: 20180321170Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.Type: ApplicationFiled: May 25, 2018Publication date: November 8, 2018Applicants: Canon U.S. Life Sciences, Inc., CALIPER LIFE SCIENCES, INC.Inventors: Ivor T. Knight, Deborah John Boles, Aaron Rulison, Wesley B. Dong, Andrew Fabans, Allen Boronkay, Edward Donlon, Robert Moti, Michael Slater, Steven A. Sundberg, Michael R. Knapp
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Patent number: 9983155Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.Type: GrantFiled: March 15, 2013Date of Patent: May 29, 2018Assignees: Canon U.S. Life Sciences, Inc., CALIPER LIFE SCIENCES, INC.Inventors: Ivor T. Knight, Deborah John Boles, Aaron Rulison, Wesley B. Dong, Andrew Fabans, Allen Boronkay, Edward Donlon, Robert Moti, Michael Slater, Steven A. Sundberg, Michael R. Knapp