Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A knuckle pin, coupling system, and method for producing a knuckle pin are provided, the knuckle pin having a cylindrical body with a longitudinal slot therein separating vertical edges of the cylindrical body, with one or more first retaining elements that span outward of the cylindrical body, and a second retainer that includes one or more of opposing apertures, and bendable legs. A method for producing the knuckle pin is provided, where a blank is stamped into a workpiece that corresponds to the pin to be produced, and the stamped workpiece is rolled to produce the pin with the slot.

Abstract: This application discloses techniques for generating and querying projective hash maps. More specifically, projective hash maps can be used for spatial hashing of data related to N-dimensional points. Each point is projected onto a projection surface to convert the three-dimensional (3D) coordinates for the point to two-dimensional (2D) coordinates associated with the projection surface. Hash values based on the 2D coordinates are then used as an index to store data in the projective hash map. Utilizing the 2D coordinates rather than the 3D coordinates allows for more efficient searches to be performed to locate points in the 3D space. In particular, projective hash maps can be utilized by graphics applications for generating images, and the improved efficiency can, for example, enable a game streaming application on a server to render images transmitted to a user device via a network at faster frame rates.

Abstract: A method of laundering fabric including the steps of: (a) contacting a detergent composition including: (i) detersive surfactant; (ii) phenolic antioxidant (iii) percarbonate; (iv) optionally, a bleach activator capable of forming C1-C11 alkyl substituted peroxycarboxylic acid; and (iv) hueing dye, with water to form a wash liquor including from 60 ppm to 2750 ppm detersive surfactant, from 0.1 ppm to 200 ppm phenolic antioxidant, from 10 ppm to 3000 ppm percarbonate, optionally from 2 ppm to 1000 ppm bleach activator, and from 0.005 to 500 pm hueing dye, and from 0.001 ppm to 10.0 ppm iron, and having a pH in the range of from greater than 7.0 to 12.0; (b) contacting fabric with the wash liquor; and (c) laundering the fabric.

Abstract: A method of laundering fabric including the steps of: (a) contacting a detergent composition including linear alkylbenzene sulphonate detersive surfactant, C8-C24 alkyl sulphate detersive surfactant and phenolic antioxidant with water to form a wash liquor including from 50 ppm to 2000 ppm linear alkylbenzene sulphonate detersive surfactant and from 10 to 750 ppm C8-C24 alkyl sulphate, from 0.1 ppm to 200 ppm phenolic antioxidant and from 0.001 ppm to 10.0 ppm iron, and having a pH in the range of from greater than 7.0 to 12.0, and wherein the molar ratio of linear alkylbenzene sulphonate detersive surfactant to C8-C24 alkyl sulphate detersive surfactant present in the wash liquor is in the range of from 0.05 to 200; (b) contacting fabric with the wash liquor; and (c) laundering the fabric.

Abstract: The present disclosure generally pertains to systems and methods for verifying operation and configuration of a lighting network. In some embodiments, a site controller is configured to receive sensor data from a plurality of sensors and to transmit commands to nodes of a lighting network for controlling light sources based on the sensor data. The site controller is also configured to store a site plan including a listing of the nodes and, for each of the nodes, indicating a number of sensors to be coupled to the respective node. The site controller is further configured to detect the sensors coupled to the nodes based on the sensor data and to compare the detected sensors to the site plan for determining whether the detect sensors is consistent with the site plan. If not, the site controller is configured to provide an alert.

Abstract: An apparatus for assembling a securing tape on a trim strip to provide a trim cap structure having a base with an assembly path, a spool assembly to dispense tape from a coil, a guide assembly to guide the strip, and an applicator assembly to guide the securing tape to the portion of the trim strip on the assembly path. A method for assembling a sign component for a sign is also disclosed.

Abstract: Lights sources may be installed in a facility without regard to their unique identifiers, which are necessary for a lighting control system to exercise control over the light sources. After installation, a graphical user interface (GUI) executed on a user's mobile device can facilitate the user's identification of the identifier of a particular light source located at a particular position. The GUI displays to the user a map of the facility, onto which the user can delineate the boundaries of a lighting area in which he intends to identify the location of light sources. The user then inputs into the GUI row and column dimensions for the lights positioned within the delineated lighting area. The GUI automatically generates and displays a plurality of selectable lighting positions arranged within the delineated area according to the selected dimensions, without the need for individual placement by the user.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to forecasting product demand. In some embodiments, a system comprise a forecasting control circuit to: apply each of a plurality of different models to forecast demand of a first product over a first historic period generating historic forecasted demands of the first product, wherein at least a first model uses selected one or more variables that are predicted to have an uncharacteristic effect on predicted demand; select one of the models and apply the model in generating a forecasted future demand, wherein the selection of the model is based on a difference between each of the generated historic forecasted demands and actual sales; and identify actions to modify inventory of the first product at the first shopping facility based on the forecasted future demand.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to forecasting product demand. In some embodiments, a system comprise a forecasting control circuit to: apply each of a plurality of different models to forecast demand of a first product over a first historic period generating historic forecasted demands of the first product, wherein at least a first model uses selected one or more variables that are predicted to have an uncharacteristic effect on predicted demand; select one of the models and apply the model in generating a forecasted future demand, wherein the selection of the model is based on a difference between each of the generated historic forecasted demands and actual sales; and identify actions to modify inventory of the first product at the first shopping facility based on the forecasted future demand.

Abstract: A goggle lens comprises a first surface (210) and a second surface (220) separated by a thickness (230, 240) of the goggle lens. The goggle lens is made up of a central region (121), a first lateral region (122) on a first side of the central region, and a second lateral region (123) on an opposite side of the central region. The first surface of the goggle lens is a portion of a first ellipse (211) and the second surface of the goggle lens is a portion of a second ellipse (221). The goggle lens complies with at least one of a MIL-PRF-31013 standard, a EA-L-1381B standard, and a FNS/PD 86-20 standard, all of which define particular specifications for impact resistance.