Patents by Inventor Aaron Smargon

Aaron Smargon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250115908
    Abstract: Provided herein are nuclear expressed antisense RNAs for interfering with a target repetitive RNA, the nuclear expressed antisense RNA comprising: (a) an oligonucleotide encoding an RNA-targeting guide comprising a sequence complementary to the target repetitive RNA; and (b) an oligonucleotide encoding a RNA binding protein (RBP)/ribonucleoprotein (RNP)-recruiting motif.
    Type: Application
    Filed: February 7, 2023
    Publication date: April 10, 2025
    Inventors: Eugene Yeo, Aaron Smargon, Samuel Hatch
  • Patent number: 12215326
    Abstract: The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a cell.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 4, 2025
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Patrick Hsu, Jonathan S. Gootenberg, Aaron Smargon
  • Patent number: 12215318
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: February 4, 2025
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Feng Zhang, Aaron Smargon, Neena Pyzocha, David Benjamin Turitz Cox, Eric S. Lander
  • Publication number: 20210166783
    Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 3, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH
    Inventors: Sergey SHMAKOV, Kira S. MAKAROVA, Yuri I. WOLF, Aaron SMARGON, Neena PYZOCHA, David COX, Winston YAN, David SCOTT, Konstantin SEVERINOV, Feng ZHANG, Eugene V. KOONIN
  • Patent number: 10689691
    Abstract: The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (ZFN, TALEN, CRISPR, and future technologies) and disease modeling among other applications.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: June 23, 2020
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Winston Yan, David A. Scott, Aaron Smargon, Mohammed Reza Mirzazadeh, Nicola Crosetto
  • Publication number: 20190093107
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: April 23, 2018
    Publication date: March 28, 2019
    Inventors: Feng Zhang, Aaron Smargon, Neena PYZOCHA, David Benjamin Turitz Cox, Eric S. Lander
  • Publication number: 20180163265
    Abstract: The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (ZFN, TALEN, CRISPR, and future technologies) and disease modeling among other applications.
    Type: Application
    Filed: June 19, 2017
    Publication date: June 14, 2018
    Inventors: Feng Zhang, Winston Yan, David A. Scott, Aaron Smargon, Mohammed Reza Mirzazadeh, Nicola Crosetto
  • Publication number: 20170306335
    Abstract: The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a cell.
    Type: Application
    Filed: June 23, 2017
    Publication date: October 26, 2017
    Inventors: Feng Zhang, Patrick Hsu, Jonathan S. Gootenberg, Aaron Smargon
  • Publication number: 20120226743
    Abstract: Customized multimedia surveys are provided in a social network environment. A user that initiates the survey provides survey content and properties. The properties include criteria specifying which users are eligible to participate in the survey. Users eligible to participate can be identified by querying a database of user properties. The survey can include text, images, audio, video, and other media. Eligible users are invited and responses are received from those who agree to participate. Survey results are compiled from the responses received. Rewards may be provided to respondents. The reward may be provided in an ecommerce system that includes both redeemable and non-redeemable points. Cash can be converted to non-redeemable points. Redeemable can be converted to cash. A transaction may transfer redeemable points from a first user to a second user with points converted from non-redeemable points to redeemable points in limited circumstances.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 6, 2012
    Applicant: VERVISE, LLC
    Inventor: Aaron Smargon
  • Publication number: 20120226603
    Abstract: An ecommerce system includes both redeemable and non-redeemable points. Cash can be converted to non-redeemable points. Redeemable can be converted to cash. A transaction may transfer redeemable points from a first user to a second user with points converted from non-redeemable points to redeemable points in limited circumstances. The ecommerce system may be used in a social network environment. Additionally, the ecommerce system may be used with a systems and methods that provide customized multimedia surveys in a social network environment.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 6, 2012
    Applicant: VERVISE, LLC
    Inventor: Aaron Smargon