Patents by Inventor Aaron STELLA

Aaron STELLA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250067617
    Abstract: Leak detection systems and methods in accordance with various aspects of the present teachings can, in various embodiments, sequester fluid leaking from the interface between a sample source and the inlet of the ion source, alert an operator as to a leak condition, and/or automatically terminate the experiment. In various aspects, a liquid leak detection system is accordance with the present teachings comprises a collection basin configured to couple to a proximal end of a conduit in fluid communication with a discharge end of an ion source of a mass spectrometer such that the proximal end of the conduit extends through the internal volume of the basin.
    Type: Application
    Filed: December 13, 2022
    Publication date: February 27, 2025
    Applicant: DH Technologies Development Pte. Ltd.
    Inventors: Amit PATEL, Aaron STELLA
  • Publication number: 20250003929
    Abstract: Disclosed are methods for detecting and quantifying target analytes in a sample by mass analysis that include detecting the presence of ions of the target analyte in the sample and quantifying the amount of the target analyte. The methods can include one or more standards (e.g., internal and/or external standards) that may be labelled (e.g., isotopically labelled).
    Type: Application
    Filed: October 26, 2022
    Publication date: January 2, 2025
    Inventors: Aaron Stella, Bradley Schneider, Subhasish Purkayastha, Leigh Bedford
  • Publication number: 20240420939
    Abstract: The presently claimed and described technology provides a sample processing system comprising at least one sample introduction device, wherein the at least one sample introduction device is configured to receive a sample; a mass analyzer coupled to the sample introduction device; a control system configured to at least control the at least one sample introduction device and/or the mass analyzer, wherein the mass analyzer is configured to perform a first mass analysis on the sample, wherein the first mass analysis is mass screening for an analyte of interest in the sample, and wherein if the analyte of interest is detected in the sample, the mass analyzer is configured to perform a second mass analysis, wherein the second mass analysis is a quantitative analysis, comprising: ionizing the sample; monitoring, by mass spectrometry, at least one product ion transition for the at least one analyte and at least one isotopic ion transition for the at least one analyte; determining intensity and/or abundance of the at
    Type: Application
    Filed: October 26, 2022
    Publication date: December 19, 2024
    Inventors: Aaron Stella, Michal Weinstock, Yongquan Lai, Subhasish Purkayastha, Scott Daniels
  • Publication number: 20240297028
    Abstract: A method for calibrating a mass spectrometry (MS) system includes: receiving at least one input through a corresponding to a calibrator in a sample, wherein the sample includes an analyte, and wherein the sample is analyzed by the MS system; automatically determining a plurality of transitions in the sample corresponding to the calibrator according to natural abundances of isotopes; automatically determining concentrations of the plurality of transitions according to a concentration of the calibrator in the sample; identifying a plurality of transitions as calibrator transitions and for identifying a different one of the plurality of transitions as an internal standard; detecting a concentration of each of the plurality of transitions and the calibrator in the sample; automatically calibrating the MS system based in part on the detected concentrations of the plurality of calibrator transitions and the internal standard; and detecting the concentration of the analyte in response to execution of the calibration
    Type: Application
    Filed: February 28, 2024
    Publication date: September 5, 2024
    Inventors: Scott DANIELS, Aaron STELLA, Michal WEINSTOCK
  • Publication number: 20240230633
    Abstract: Methods and kits for preparing liquid samples are presently claimed and described. The method may include treating a liquid sample with enzyme-conjugated magnetic beads are suspended in a buffer solution that comprises at least one internal standard, hydrolyzing the liquid sample to prepare a hydrolysate, and purifying the hydrolysate with magnetic based purification. Kits for preparing a liquid sample can include the, a liquid chromatography column, one or more solvents to be used as mobile phases, one or more calibrant solutions, and instructions for use.
    Type: Application
    Filed: May 18, 2022
    Publication date: July 11, 2024
    Inventors: Aaron STELLA, Subhasish PURKAYASTHA
  • Publication number: 20240177984
    Abstract: Methods of detecting at least one analyte in at least one liquid sample are described.
    Type: Application
    Filed: March 21, 2022
    Publication date: May 30, 2024
    Inventors: Bradley Schneider, Leigh Bedford, Aaron Stella, Subhasish Purkayastha
  • Publication number: 20240168040
    Abstract: Methods and kits for preparing liquid samples are presently claimed and described. The method may include treating liquid sample with a hydrolysis enzyme, hydrolyzing the liquid sample to prepare a hydrolysate, and purifying the hydrolysate with magnetic based purification. In certain aspects, the hydrolysis enzyme is bound to a magnetic bead or a magnetic particle. Kits for preparing a liquid sample can include a hydrolysis enzyme, magnetic beads or magnetic particles, one or more internal standards, a liquid chromatography column and one or more solvents to be used as mobile phases, one or more calibrant solutions and instructions for use.
    Type: Application
    Filed: March 21, 2022
    Publication date: May 23, 2024
    Inventors: Aaron Stella, Chang Liu, Yuguan Liu, Subhasish Purkayastha
  • Publication number: 20230333130
    Abstract: An analyzer and sample handling system suitable for retrieving and processing a sample housed within a suitably configured reaction vessel, and then discarding the used reaction vessel by vertically or axially pushing downward on the vessel supported in a suitably configured tray with a pressing member that forms part of an autosampler assembly are disclosed herein.
    Type: Application
    Filed: July 14, 2021
    Publication date: October 19, 2023
    Applicant: DH Technologies Development Pte. Ltd.
    Inventor: Aaron STELLA