Patents by Inventor Aaron W. FELDMAN

Aaron W. FELDMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220144875
    Abstract: Disclosed herein, inter alia, are methods for modifying a nucleotide, for example including reacting a nucleotide having a 3?-O-oxime moiety such as with a reagent having an —ONH2 moiety to produce a nucleotide having a 3?-O—NH2 moiety such as wherein the reagent having the —ONH2 moiety further comprises alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, or (heteroalicyclyl)alkyl.
    Type: Application
    Filed: September 17, 2021
    Publication date: May 12, 2022
    Inventors: Denis Malyshev, Aaron W. Feldman
  • Patent number: 11180520
    Abstract: Disclosed herein, inter alia, are methods for modifying a nucleotide, for example including reacting a nucleotide having a 3?-O-oxime moiety such as with a reagent having an —ONH2 moiety to produce a nucleotide having a 3?-O—NH2 moiety such as wherein the reagent having the —ONH2 moiety further comprises alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, or (heteroalicyclyl)alkyl.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: November 23, 2021
    Assignee: OMNIOME, INC.
    Inventors: Denis Malyshev, Aaron W. Feldman
  • Publication number: 20210222147
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: March 9, 2021
    Publication date: July 22, 2021
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
  • Publication number: 20210070795
    Abstract: Disclosed herein, inter alia, are methods for modifying a nucleotide, for example including reacting a nucleotide having a 3?-O-oxime moiety with a reagent having the structure R2-ONH2 to produce a nucleotide having a 3?-O—NH2 moiety, wherein R2 is independently alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, or an optionally substituted variant thereof.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 11, 2021
    Inventors: Denis Malyshev, Aaron W. Feldman
  • Publication number: 20200392550
    Abstract: Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Inventors: Floyd E. ROMESBERG, Vivian T. DIEN, Aaron W. FELDMAN, Rebekah J. KARADEEMA, Lingjun LI, Michael P. LEDBETTER, Anne Xiaozhou ZHOU
  • Publication number: 20200224234
    Abstract: Disclosed herein are in vivo methods, compositions, and kits for producing nucleic acids which comprises at least one unnatural base. Disclosed herein are in vivo methods of producing a nucleic acid with an expanded genetic alphabet, the method comprising incorporatin at least one unnatural base in the nucleic acid. Disclosed herein are semi-synthetic organisms comprising an expanded genetic alphabet, wherein the genetic alphabet comprises at least one unnatural base. Disclosed herein are compositions that include a heterologous or recombinant polymerase and methods of use thereof. Further, disclosed herein are kits that are useful for stably incorporating an unnatural nucleic acid into a nucleic acid molecule, e.g., using the methods provided by the present invention in in vitro condition or under a cell free condition.
    Type: Application
    Filed: July 10, 2018
    Publication date: July 16, 2020
    Inventors: Floyd E. ROMESBERG, Yorke ZHANG, Aaron W. FELDMAN, Vivian T. DIEN
  • Publication number: 20200131555
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: July 10, 2018
    Publication date: April 30, 2020
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
  • Publication number: 20190376054
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: August 2, 2019
    Publication date: December 12, 2019
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG