Abstract: A dosage unit comprises a substrate comprising a first polymer; a deposit, including an active ingredient; and a cover layer comprising a second polymer, wherein the cover layer covers the deposit and is joined to the first surface of the substrate by a bond that encircles the deposit and wherein at least one of the first and second polymers is a graft co-polymer. The dosage unit wherein said first and second polymers may be the same, and also the graft co-polymer may be a polyvinyl alcohol-polyethylene glycol graft co-polymer. Also disclosed is a dosage unit wherein the deposit is formed on the substrate by electrostatic dry drug deposition. The dosage unit may also include a polymer that is a graft co-polymer; and an active ingredient, and the graft co-polymer may be polyvinyl alcohol-polyethylene glycol.

Abstract: A method for accomplishing a plurality of combinatorial processes in parallel using a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array has a top feedthru plate, a center distribution plate and a bottom cell plate. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate includes a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.

Abstract: Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising:an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing;a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; andan optical detection device for quantifying the amount of grains deposited.

Abstract: The invention provides methods of performing a synthetic process in a liquid distribution system having reaction cells, by pumping at least one reagent into a reaction cell.

Abstract: A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate.

Abstract: An electrohydrodynamic (EHD) receptor that incorporates microchannels and reservoir(s) for selectively dispensing fluid from the reservoir(s) to a specific location, e.g., onto the surface of the receptor.

Abstract: A liquid distribution system comprising a reaction cell, two or more feeder channels, a separate conduit for each feeder channel connecting that feeder channel to the reaction cell, and a expansion valve for each conduit, wherein the expansion valve has an expanded state that fills a cross-section of the conduit and prevents fluid flow through the conduit and an contracted state that allows fluid flow through the conduit is disclosed.

Abstract: The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir and a beta reservoir, a first set of parallel and adjacent first and second feeder channels and a second set of parallel and adjacent third and fourth feeder channels which are offset from the first and second feeder channels, wherein (a) the first and third feeder channels are connected to the alpha reservoir via a first connector channel that is situated above or below the second and fourth feeder channels and are independent of the beta reservoir and (b) the second and fourth feeder channels are connected to the beta reservoir via a second connector channel that is situated above or below the first and third feeder channels and are independent of the alpha reservoir. The distribution system is preferably a microscale distribution system.

Abstract: A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate.

Abstract: A plurality of CCD imaging devices are bonded aligned to a color separating prism using glass rods bonded to prism support plates, the CCD devices being bonded to the rods. The rods and devices are aligned in a complex fixture which generally inhibits direct exposure to light of the adhesive at the different joints. A light responsive adhesive having a long pot life and short cure time is cured by exposing the ends of the glass rods to a light flash. The adhesive along the side walls of the rods cures in response to the indirect exposure of scattered light transmitted through the rod side walls.

Abstract: A solid-state detector assembly for a television camera includes a beam-splitting prism having an inlet port and three outlet ports. A pair of mounting plates each having opposed major surfaces extend across the top and bottom of the prism and have a major surface secured to the prism. Each of the mounting plates has a separate pair of spaced slots in its edge adjacent each of the outlet ports. Each of the slots in one of the mounting plates is aligned with a separate slot in the other mounting plate. A separate pair detector support rods extends between the mounting plates adjacent each outlet port. Each of the detector support rods extends through the slots in the mounting plates and projects beyond the major surfaces of the mounting plates. A separate detector is mounted on each of the pair support rods and extends across an outlet port.

Abstract: Multilayer photoresist recording media containing an absorptive layer are improved by forming the absorptive layer from a composition comprising PMMA or a copolymer of methylmethacrylate and methacrylic acid, certain dyes such as hydroxyazobenzoic acid or Sudan Orange G and a suitable solvent. The dyes are insoluble in the solvent of an overlying photoresist layer. The media are substantially free of loss of resolution due to dissolution of the dye into the photoresist layer.

Abstract: A method of metallizing a phosphor screen including the steps of coating the phosphor screen with an aqueous emulsion containing an acrylic copolymer, drying the coating and depositing a metal layer on the dry coating, the copolymer consists essentially of about34 to 80 weight percent of one member of the group consisting of methyl methacrylate and ethyl methacrylate,20 to 60 weight percent ethyl acrylate and1 to 14 weight percent methacrylic acid.The emulsion may contain minor amounts of (a) colloidal silica, (b) water-soluble polymer and/or (c) dispersing agent.

Abstract: Improved perpendicular alignment can be imparted to nematic liquid crystal cells by coating the cell walls with a perfluorinated polymer applied to the cell walls by glow discharge in the presence of a perfluorinated monomer. The coated cell walls are thermally stable at least up to about 525.degree. C.