Abstract: A calibration system and method for calibrating an instrument are provided. The system comprises at least one sensor, a processor, and a memory comprising instructions which, when executed by the processor, configure the processor to perform the method. The method comprises obtaining a series of sensor readings, determining variations between changes in successive (or near successive) sensor readings from the series of sensor readings, estimating a stabilization point of the sensor readings by identifying at least one gas sensor reading from series of sensor readings at which the change in sensor reading from at least one previous sensor readings is small relative to the variations, and adjusting a parameter in the instrument that represents an association between sensor readings and a known physical quantity based on the stabilization point.