Abstract: Gate-all-around integrated circuit structures having an insulator fin on an insulator substrate, and methods of fabricating gate-all-around integrated circuit structures having an insulator fin on an insulator substrate, are described. For example, an integrated circuit structure includes an insulator fin on an insulator substrate. A vertical arrangement of horizontal semiconductor nanowires is over the insulator fin. A gate stack surrounds a channel region of the vertical arrangement of horizontal semiconductor nanowires, and the gate stack is overlying the insulator fin. A pair of epitaxial source or drain structures is at first and second ends of the vertical arrangement of horizontal semiconductor nanowires and at first and second ends of the insulator fin.

Abstract: The invention relates to combination therapies employing anti-PD1/anti-LAG3 bispecific antibody and a CD20 T cell-activating bispecific antibody, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.

Abstract: The present invention relates to anti-LAG3 antibodies, to methods of producing these molecules and methods of using the same.

Abstract: An additive fabrication approach involves fabricating a platform on a build plate. The fabrication system is then calibrated based on the fabricated platform, and an object is then fabricating on the fabricated platform according to the calibration.

Abstract: A method for additive manufacturing includes forming an object including depositing a first material including a first coloring component and a second material including a second coloring component, wherein both the first material and the second material further include a corresponding fluorescent component, scanning the object, including causing an emission of an optical signal from the object, wherein the emission of the optical signal is caused at least in part by an emission from the fluorescent components interacting with the first coloring component and the second coloring component as it passes from the fluorescent components to the surface of the object, sensing the emission of the optical signal, and determining presence of the first material and the second material based at least in part on the sensed emission of the optical signal.

Abstract: A profilometer provides, to a controller, a feedback signal indicative of topography of an exposed surface of an object that is being manufactured by a 3d printer. The profilometer includes an emitter and a camera. The emitter illuminates a region of surface of the object with a pattern having an edge that defines a boundary of an illuminated portion of the surface. The camera receives an image that transitions between a first state in which the edge is visible in the image at a location that is indicative of the surface's depth and a second state in which the edge is not visible at all. From this second state, the controller obtains information representative of a depth of the surface.

Abstract: The present invention relates to a positioning and exposure device (1) for the defined arrangement on at least one body part (2, 3) of a living being (4) and for exposing the body part (2, 3) to radiation for determining at least one vital parameter of the living being (4).

Abstract: The blood pressure measuring device (1) is designed as a photoplethysmographic measuring system which functions according to the “vascular unloading technique”. Metrological components and a pressure generating and pressure control system are accommodated in the base part (3). The fitted cuff part (2) has an ergonomic palm support (4), two finger supports (6) divided from one another by a web (5), and also a receiving part (7) which comprises two receiving tubes (9) for fingers. The cuff part (2) projects beyond the base part (3), both towards the front and also towards the rear, and covers the base part (3) almost completely, i.e. by more than 90%. The lateral attachment of the cable (8) facing in the direction of the forearm has the advantage that the cable can be guided along the patient's arm, the wrist does not rub against the cable (8), and in particular the carpal tunnel is also protected.

Abstract: The two inflatable sleeve cushions (10) which can be arranged in the receiving tubes (9) are each connected by means of a connection (11) at the interface between sleeve part (2) and base part (3) to the pressure generation and pressure control system in the base part (3). A valve device is preferably provided on the connection (11). The channels (19) that connect the respective connection (11) to the respective sleeve cushion (20) are formed in the main body (21) of the receiving body, said main body being produced from plastic by means of injection moulding, and are covered towards the outside by means of a cover (20). The connections (11) are disposed one behind the other in the direction parallel to the axial direction of the receiving tubes (9). From there, each channel (19) is first guided upwards, then diagonally to the side, and finally downwards to the fluid access opening (22) of the respective sleeve cushion (10).

Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: A method for managing the temperature of three-dimensional object during additive manufacturing includes depositing material on a partial fabrication of the three-dimensional object, determining thermal properties of the three-dimensional object after depositing the material, and controlling cooling of the object according to said thermal properties. In some examples, the determining of the thermal properties includes determining a temperature variation across the object and controlling position-dependent cooling of the object in a feedback arrangement. Resulting uniform temperature of the object under fabrication can improve dimensional accuracy and material properties of the object.

Abstract: This invention releases to systems and methods for detecting the presence and quantity of a target nucleic acid in a sample using dPCR and PIP encapsulated monodisperse droplets.

Abstract: A profilometer provides, to a controller, a feedback signal indicative of topography of an exposed surface of an object that is being manufactured by a 3d printer. The profilometer includes an emitter and a camera. The emitter illuminates a region of surface of the object with a pattern having an edge that defines a boundary of an illuminated portion of the surface. The camera receives an image that transitions between a first state in which the edge is visible in the image at a location that is indicative of the surface's depth and a second state in which the edge is not visible at all. From this second state, the controller obtains information representative of a depth of the surface.

Abstract: A method for managing the temperature of three-dimensional object during additive manufacturing includes depositing material on a partial fabrication of the three-dimensional object, determining thermal properties of the three-dimensional object after depositing the material, and controlling cooling of the object according to said thermal properties. In some examples, the determining of the thermal properties includes determining a temperature variation across the object and controlling position-dependent cooling of the object in a feedback arrangement. Resulting uniform temperature of the object under fabrication can improve dimensional accuracy and material properties of the object.

Abstract: An additive fabrication approach involves fabricating a platform on a build plate. The fabrication system is then calibrated based on the fabricated platform, and an object is then fabricating on the fabricated platform according to the calibration.

Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: A method includes generating correction data for a construction material that is used by an additive-manufacturing machine to manufacture an object. This correction data compensates for an interaction of the construction material with first radiation that has been used to illuminate the construction material.

Abstract: An approach to improving optical scanning increases the strength of optical reflection from the build material during fabrication. In some examples, the approach makes use of an additive (or a combination of multiple additives) that increases the received signal strength and/or improves the received signal-to-noise ratio in optical scanning for industrial metrology. Elements not naturally present in the material are introduced in the additives in order to increase fluorescence, scattering or luminescence. Such additives may include one or more of: small molecules, polymers, peptides, proteins, metal or semiconductive nanoparticles, and silicate nanoparticles.

Abstract: Disclosed herein is a base device with a pump device for applying pressure to a working fluid and a body contact device that can be detachably coupled to one another. A housing of the base device has a contact surface for the body contact device where the contact surface has a passage which can be closed by means of a closing member of a valve device. A spring is provided for applying spring force to move the closing member into a position that closes the passage. The body contact device has a pressure applicator, which can be acted upon by the working fluid, to apply pressure to the finger and a sealing element for creating a fluid connection with the base device. The body contact device has a deflecting means for deflecting the closing member against the spring force in the operating configuration.

Abstract: The invention relates to a measuring device for continuously determining the intra-arterial blood pressure in a finger of a hand, the measuring device comprises a base part and a cuff part. A light source for near-infrared light and a photodetector are provided for the finger. The light sources and the photodetectors are connected to an associated optical emission surface or optical collector surface via a respective so-called light pipe for coupling emitted light into the finger tissue or decoupling non-absorbed light from the finger tissue. The cuff-side and base-part-side sections of the light pipes are connected to one another via separable optical contact points at the interface between the cuff part and the base part. On the base-part side, a cover glass closes flush with the housing of the base part and is attached to the contact points.