Patents by Inventor Aaron Winkler

Aaron Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210054433
    Abstract: The present invention relates to a method of identifying a heterologous polypeptide having enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA in (the cytosol of) of a yeast cell comprising: a) providing a mutated yeast cell comprising a deletion of at least one gene of the (PDH) by-pass, selected from the genes encoding the enzymes pyruvate decarboxylase (PDC), acetaldehyde dehydrogenase (ALD), and acetyl-CoA synthetase (ACS); b) transforming said mutated yeast cell with an expression vector comprising a heterologous nucleotide sequence encoding a candidate polypeptide having potential enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA; c) testing said recombinant mutated yeast cell for its ability to grown on minimal medium containing glucose as sole carbon source, and d) identifying said candidate polypeptide as a heterologous polypeptide having enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA in (the cytoso
    Type: Application
    Filed: October 27, 2020
    Publication date: February 25, 2021
    Inventors: Ulrike Maria MUELLER, Liang Wu, Lourina Madeleine Raamsdonk, Aaron Winkler
  • Publication number: 20090156537
    Abstract: The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.
    Type: Application
    Filed: October 24, 2008
    Publication date: June 18, 2009
    Applicant: Wyeth
    Inventors: Michael R. Bowman, Maximilliam T. Follettie, Hang Chen, Cara Williams, Aaron Winkler, Debra Ellis, Wei Liu
  • Publication number: 20090010942
    Abstract: Novel primate chitinases (pNC) and nucleic acids encoding these chitinases are disclosed. The pNCs of the invention are homologous to human acidic mammalian chitinases (hAMCase) and human chitotriosidase, in terms of their exon/intron genomic structure and conserved catalytic sites. The polypeptides and nucleic acids of the invention can be used to develop, and/or screen for, modulators of chitinase-activities, e.g., antisense, antibodies, RNAi. The modulators identified using methods and reagents disclosed herein can be used to reduce chitinase-associated inflammatory conditions.
    Type: Application
    Filed: May 19, 2008
    Publication date: January 8, 2009
    Applicant: WYETH
    Inventors: Rustem KRYKBAEV, Padmalatha S. REDDY, Aaron WINKLER, Lori J. FITZ
  • Publication number: 20070031950
    Abstract: A yeast strain, wherein the yeast strain is transformed with at least one copy of a gene coding for D-lactate dehydrogenase functionally linked to a promoter sequence allowing the expression of the gene in the yeast strain and the yeast strain has undergone disruption of one or more pyruvate decarboxylase genes or pyruvate dehydrogenase genes. Also, a method of producing D-lactic acid including culturing such a yeast strain in a medium and recovering D-lactic acid.
    Type: Application
    Filed: June 21, 2006
    Publication date: February 8, 2007
    Inventor: Aaron Winkler
  • Publication number: 20060148050
    Abstract: Yeast strains transformed with at least one copy of a gene coding for lactic dehydrogenase (LDH) and further modified for the production of lactic acid with high yield and productivities, are described.
    Type: Application
    Filed: December 27, 2005
    Publication date: July 6, 2006
    Inventors: Danilo Porro, Michele Bianchi, Bianca Ranzi, Laura Frontali, Marina Vai, Aaron Winkler, Lilia Alberghina
  • Publication number: 20040234517
    Abstract: The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.
    Type: Application
    Filed: March 4, 2004
    Publication date: November 25, 2004
    Applicant: WYETH
    Inventors: Michael R. Bowman, Maximillian T. Follettie, Hang Chen, Cara Williams, Aaron Winkler, Debra Ellis, Wei Liu