Abstract: The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.

Abstract: A method for multiple transition monitoring using a liquid chromatography mass spectrometry device is disclosed and comprises determining at least one data set from at least one data base, the data set comprising at least one reference measurement of at least one transition of at least one analyte with the liquid chromatography mass spectrometry device; determining at least one reference peak information of the transition of the analyte using an initial setting of a measurement window, wherein the measurement window is defined by a time frame of retention times; determining an actual setting of the measurement window considering the reference peak information, wherein the determining comprises adjusting the time frame; measuring the transition of the analyte with the liquid chromatography mass spectrometry device and determining a measured peak information of the transition of the analyte using the actual setting of the measurement window.