Patents by Inventor Abbey Pierson
Abbey Pierson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230194395Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.Type: ApplicationFiled: February 16, 2023Publication date: June 22, 2023Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts
-
Publication number: 20230184721Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.Type: ApplicationFiled: February 9, 2023Publication date: June 15, 2023Inventors: David Chafin, Michael Otter, Abbey Pierson, Jefferson Curtis Taft
-
Patent number: 11624684Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.Type: GrantFiled: January 22, 2018Date of Patent: April 11, 2023Assignee: Ventana Medical Systems, Inc.Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts
-
Patent number: 11614426Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.Type: GrantFiled: February 27, 2019Date of Patent: March 28, 2023Assignee: Ventana Medical Systems, Inc.Inventors: David Chafin, Michael Otter, Abbey Pierson, Jefferson Curtis Taft
-
Publication number: 20190195831Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.Type: ApplicationFiled: February 27, 2019Publication date: June 27, 2019Inventors: David Chafin, Michael Otter, Abbey Pierson, Jefferson Curtis Taft
-
Patent number: 10267769Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.Type: GrantFiled: March 4, 2011Date of Patent: April 23, 2019Assignee: Ventana Medical Systems, Inc.Inventors: Michael Otter, David Chafin, Abbey Pierson, Jefferson Curtis Taft
-
Publication number: 20190086300Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.Type: ApplicationFiled: January 22, 2018Publication date: March 21, 2019Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts
-
Patent number: 10126216Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.Type: GrantFiled: February 13, 2012Date of Patent: November 13, 2018Assignee: Ventana Medical Systems, Inc.Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts
-
Publication number: 20170184477Abstract: The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.Type: ApplicationFiled: March 10, 2017Publication date: June 29, 2017Inventors: Daniel Bauer, David Chafin, Michael Otter, Abbey Pierson Theiss
-
Publication number: 20120329088Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.Type: ApplicationFiled: March 4, 2011Publication date: December 27, 2012Applicant: Ventana Medical Systems, Inc.Inventors: Michael Otter, David Chafin, Abbey Pierson, Jefferson Curtis Taft
-
Publication number: 20120214195Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.Type: ApplicationFiled: February 13, 2012Publication date: August 23, 2012Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts