Abstract: There is provided a single variable domain T-cell receptor (svd-TCR) comprising a first TCR variable domain, the first TCR variable domain specifically binding to an epitope, that is not a superantigen, in the absence of a second TCR variable domain. Also provided are compositions and cells comprising the svd-TCR as well as methods of identifying the svd-TCR.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: Various embodiments relating to selection of a user interface object displayed on a graphical user interface based on eye gaze are disclosed. In one embodiment, a selection input may be received. A plurality of eye gaze samples at different times within a time window may be evaluated. The time window may be selected based on a time at which the selection input is detected. A user interface object may be selected based on the plurality of eye gaze samples.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: Embodiments that relate to converting audio inputs from an environment into text are disclosed. For example, in one disclosed embodiment a speech conversion program receives audio inputs from a microphone array of a head-mounted display device. Image data is captured from the environment, and one or more possible faces are detected from image data. Eye-tracking data is used to determine a target face on which a user is focused. A beamforming technique is applied to at least a portion of the audio inputs to identify target audio inputs that are associated with the target face. The target audio inputs are converted into text that is displayed via a transparent display of the head-mounted display device.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: Various embodiments relating to selection of a user interface object displayed on a graphical user interface based on eye gaze are disclosed. In one embodiment, a selection input may be received. A plurality of eye gaze samples at different times within a time window may be evaluated. The time window may be selected based on a time at which the selection input is detected. A user interface object may be selected based on the plurality of eye gaze samples.

Abstract: A system and related methods for an augmented reality help system in a head-mounted display device are provided. In one example, the head-mounted display device includes a plurality of sensors and a display system for presenting holographic objects. An augmented reality help program is configured to receive one or more user biometric parameters from the plurality of sensors. Based on the user biometric parameters, the program determines that the user is experiencing a stress response, and presents help content to the user via the head-mounted display device.

Abstract: Embodiments that relate to converting audio inputs from an environment into text are disclosed. For example, in one disclosed embodiment a speech conversion program receives audio inputs from a microphone array of a head-mounted display device. Image data is captured from the environment, and one or more possible faces are detected from image data. Eye-tracking data is used to determine a target face on which a user is focused. A beamforming technique is applied to at least a portion of the audio inputs to identify target audio inputs that are associated with the target face. The target audio inputs are converted into text that is displayed via a transparent display of the head-mounted display device.

Abstract: A system and related methods for an augmented reality help system in a head-mounted display device are provided. In one example, the head-mounted display device includes a plurality of sensors and a display system for presenting holographic objects. An augmented reality help program is configured to receive one or more user biometric parameters from the plurality of sensors. Based on the user biometric parameters, the program determines that the user is experiencing a stress response, and presents help content to the user via the head-mounted display device.