Patents by Inventor Abd Higazi

Abd Higazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasminogen activator mutants as anti-fibrinolytic agents
    Patent number: 10188706
    Abstract: The invention relates to an anti fibrinolytic composition comprising at least one tPA mutant that carries at least one point mutation substituting Ser481 to Ala on tPA, said mutant inhibits the fibrinolytic activity of at least one of tPA and uPA and therefore may be used for treating disorders associated with fibrinolytic processes, specifically, coagulopathies, thrombocytopenia and bleeding. The invention further provides methods and uses of the mutants of the invention.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: January 29, 2019
    Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED
    Inventors: Abd Higazi, Nuha Hijazi
  • PLASMINOGEN ACTIVATOR MUTANTS AS ANTIFIBRINOLYTIC AGENTS
    Publication number: 20150190482
    Abstract: The invention relates to an anti fibrinolytic composition comprising at least one tPA mutant that carries at least one point mutation substituting Ser481 to Ala on tPA, said mutant inhibits the fibrinolytic activity of at least one of tPA and uPA and therefore may be used for treating disorders associated with fibrinolytic processes, specifically, coagulopathies, thrombocytopenia and bleeding. The invention further provides methods and uses of the mutants of the invention.
    Type: Application
    Filed: July 2, 2013
    Publication date: July 9, 2015
    Inventors: Abd Higazi, Nuha Hijazi
  • tPA mutant in the treatment of acute brain injury and neurodegenerative disorders
    Patent number: 9072737
    Abstract: The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: July 7, 2015
    Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
    Inventors: Abd Higazi, Nuha Hijazi
  • tPA MUTANT IN THE TREATMENT OF ACUTE BRAIN INJURY AND NEURODEGENERATIVE DISORDERS
    Publication number: 20110008313
    Abstract: The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 13, 2011
    Inventors: Abd Higazi, Nuha Hijazi
  • Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
    Publication number: 20080050389
    Abstract: Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
    Type: Application
    Filed: December 18, 2006
    Publication date: February 28, 2008
    Inventors: Vladimir Muzykantov, Abd Higazi, Juan Murciano, Douglas Cines, Ronald Taylor