Patents by Inventor Abdelghani OUKHALED

Abdelghani OUKHALED has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrical detection process for peptides, proteins and other macromolecules
    Patent number: 11002657
    Abstract: An aerolysin nanopore or a nanotube is used for the electrical detection of peptides, proteins separated by at least one amino acid and other macromolecules such as polysaccharides or synthetic or natural polymers present in a preparation where said nanopore or nanotube is inserted into a lipid membrane which is subjected to a difference in potential greater than ?160 mV, in a reaction medium having an alkali metal halide electrolyte solution with a concentration of less than 6M and at a temperature of less than 40° C., and where said use is intended to differentiate said peptides, proteins and other molecules according to their length and their mass. Application to the sequencing of peptides and other molecules to differentiate them according to their length and mass with an amino acid-level or monomer-level resolution and to medical diagnosis.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 11, 2021
    Assignees: EXCILONE, UNIVERSITÉ DE CERGY PONTOISE, UNIVERSITÉ EVRY VAL D'ESSONNE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS
    Inventors: Juan Pelta, Abdelghani Oukhaled, Philippe Manivet, Fabien Piguet, Hadjer Ouldali, Zuzana Krupova, Pierre Defrenaix
  • ELECTRICAL DETECTION PROCESS FOR PEPTIDES, PROTEINS AND OTHER MACROMOLECULES
    Publication number: 20190317006
    Abstract: An aerolysin nanopore or a nanotube is used for the electrical detection of peptides, proteins separated by at least one amino acid and other macromolecules such as polysaccharides or synthetic or natural polymers present in a preparation where said nanopore or nanotube is inserted into a lipid membrane which is subjected to a difference in potential greater than ?160 mV, in a reaction medium having an alkali metal halide electrolyte solution with a concentration of less than 6M and at a temperature of less than 40° C., and where said use is intended to differentiate said peptides, proteins and other molecules according to their length and their mass. Application to the sequencing of peptides and other molecules to differentiate them according to their length and mass with an amino acid-level or monomer-level resolution and to medical diagnosis.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 17, 2019
    Applicants: EXCILONE, UNIVERSITÉ DE CERGY PONTOISE, UNIVERSITÉ EVRY VAL D'ESSONNE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS
    Inventors: Juan PELTA, Abdelghani OUKHALED, Philippe MANIVET, Fabien PIGUET, Hadjer OULDALI, Zuzana KRUPOVA, Pierre DEFRENAIX