Patents by Inventor Abdelmalik Slassi

Abdelmalik Slassi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic Piperazines as Metabotropic Glutatmate Receptor Antagonists
    Publication number: 20080312240
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: December 18, 2008
    Applicant: AstraZeneca AB
    Inventors: Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Guang-Ri Sun, Tao Xin, Alexander Minidis, Peter Dove
  • Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists
    Publication number: 20080312246
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: December 18, 2008
    Applicant: AstraZeneca AB
    Inventors: Louise Edwards, Abdelmalik Slassi, Methvin Isaac, Donald Mcleod, Tao Xin
  • Oxadiazole Derivatives and Their Use as Metabotropic Glutamate Receptor Potentiators 842
    Publication number: 20080306077
    Abstract: Compounds of Formula I: wherein R1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: June 6, 2008
    Publication date: December 11, 2008
    Applicant: AstraZeneca AB
    Inventors: Joshua Clayton, Ian Egle, James Empfield, James Folmer, Methvin Isaac, Fupeng Ma, Abdelmalik Slassi
  • Metabotropic Glutamate Receptor Oxadiazole Ligands and Their Use as Potentiators 841
    Publication number: 20080306088
    Abstract: Compounds of Formula I: wherein R1, R2, R3, R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: June 6, 2008
    Publication date: December 11, 2008
    Applicant: AstraZeneca AB
    Inventors: Joshua Clayton, Ian Egle, James Empfield, James Folmer, Methvin Isaac, Fupeng Ma, Abdelmalik Slassi
  • Compounds
    Patent number: 7456200
    Abstract: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing compounds of the formula I and to the use of compounds of the formula I in therapy.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: November 25, 2008
    Assignee: Astrazeneca AB
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald A. McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas M. Stormann, David Wensbo, Tao Xin, Helena Gyback, Martin Johansson, Annika Kers, John Malmberg, Alexander Minidis, Karin Oscarsson, Mangus Waldman, Ulrika Yngve, Christoffer Osterwall
  • 5-(Phenylisoxazolylethoxy) - Triazol- 3 -Yl Substituted Pyridine Compounds for the Treatment of Neurological, Psychiatric or Pain Disorders
    Publication number: 20080227824
    Abstract: The present invention is directed to novel compounds of formula (I)/(II)/(III), their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: September 20, 2006
    Publication date: September 18, 2008
    Applicant: Astrazeneca AB
    Inventors: Alexander Minidis, David Wensbo, Abdelmalik Slassi, Methvin Isaac, Caroline Ericsson, Veronica Profir, Per-Olov Bergstrom, Louise Edwards, Jalaj Arora, Tao Xin
  • Metabotropic Glutamate-Receptor-Potentiating Isoindolones
    Publication number: 20080227794
    Abstract: Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
    Type: Application
    Filed: February 15, 2006
    Publication date: September 18, 2008
    Inventors: Bradford Van Wagenen, Radhakrishnan Ukkiramapandian, Joshua Clayton, Ian Egle, James R. Empfield, Methvin Isaac, Fupeng Ma, Abdelmalik Slassi, Gary Steelman, Rebecca Urbanek, Sally Walsh
  • Acetylenic Piperazines as Metabotropic Glutamate Receptor Antagonists
    Publication number: 20080194571
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, B, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.
    Type: Application
    Filed: August 4, 2006
    Publication date: August 14, 2008
    Applicant: AstraZeneca AB
    Inventors: Louise Edwards, Mithvin Isaac, Abdelmalik Slassi, Guang-Ri Sun, Peter Dove, Erwan Arzel
  • MgluR5 modulators
    Publication number: 20080125436
    Abstract: The present invention is directed to compounds of formula I: Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
    Type: Application
    Filed: September 25, 2007
    Publication date: May 29, 2008
    Applicant: AstraZeneca AB
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Peter Dove, Tao Xin, Tomislav Stefanac
  • Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
    Publication number: 20080125431
    Abstract: Compounds in accord with Formula I: wherein R1, L, A, B, D, E, m, n, x and y are as defined in the description, processes for the preparation of such compounds and to new intermediates employed in the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds in therapy and for the treatment of diseases mentioned in the specification.
    Type: Application
    Filed: September 12, 2007
    Publication date: May 29, 2008
    Applicant: ASTRAZENECA
    Inventors: Ian Egle, Babu Joseph, Abdelmalik Slassi, Methvin Isaac, Fupeng Ma, Joshua Clayton
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080045571
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: February 21, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015204
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015234
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Azaindoles Having Serotonin Receptor Affinity
    Publication number: 20080004307
    Abstract: Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein A, B, D, E, R1 to R3 and n are described herein. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
    Type: Application
    Filed: August 7, 2007
    Publication date: January 3, 2008
    Applicant: NPS Allelix Corp.
    Inventors: Louise Edwards, Abdelmalik Slassi, Ashok Tehim, Tao Xin
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20070293545
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: December 20, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
    Publication number: 20070275966
    Abstract: The present invention is directed to compounds of Formula I: Wherein R1, R2, Y, m and n are further defined in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
    Type: Application
    Filed: December 6, 2006
    Publication date: November 29, 2007
    Applicants: NPS PHARMACEUTICALS, INC., AstraZeneca AB
    Inventors: Abdelmalik Slassi, Methvin Isaac, Ian Egle, Fupeng Ma, Babu Joseph, Joshua Clayton, Krzysztof Swierczek
  • NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS
    Publication number: 20070270469
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 22, 2007
    Inventors: Alexander MINIDIS, David WENSBO, Methvin ISAAC, Abdelmalik SLASSI, Jalaj ARORA, Tao XIN, Louise Edwards, Caroline ERIKSSON, Veronica PROFIR, Per-Olov BERGSTROM
  • NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS
    Publication number: 20070270468
    Abstract: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 22, 2007
    Inventors: Alexander MINIDIS, David WENSBO, Methvin ISAAC, Abdelmalik SLASSI, Jalaj ARORA, Tao XIN, Louise EDWARDS, Caroline ERIKSSON, Veronica PROFIR, Per-Olov BERGSTROM
  • MGluR5 modulators I
    Publication number: 20070259862
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Andreas Wallberg, Karolina Nilsson, Bjorn Holm, Mats Nagard, Kenneth Granberg, Abdelmalik Slassi, Louise Edwards, Methvin Isaac, Tao Xin, Tomislav Stefanac
  • MGluR5 modulators IV
    Publication number: 20070259923
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Andreas Wallberg, Tomislav Stefanac