Patents by Inventor Abdesslame Nazih

Abdesslame Nazih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxime derivatives of 3,5-seco-4-nor-cholestane, pharmaceutical compositions containing same, and method for preparing same
    Patent number: 9115059
    Abstract: The invention relates to novel chemical compounds, in particular oxime derivatives of 3,5-seco-4-nor-cholestane, to the application thereof as drugs, in particular cytoprotective drugs, and more particularly as neuroprotective, cardioprotective and/or hepatoprotective drugs.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: August 25, 2015
    Assignee: TROPHOS
    Inventors: Cyrille Drouot, Abdesslame Nazih, Corinne Chaimbault
  • NOXEL OXIME DERIVATIVES OF 3, 5-SECO-4-NOR-CHOLESTANE, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHOD FOR PREPARING SAME
    Publication number: 20110275680
    Abstract: The invention relates to novel chemical compounds, in particular oxime derivatives of 3,5-seco-4-nor-cholestane, to the application thereof as drugs, in particular cytoprotective drugs, and more particularly as neuroprotective, cardioprotective and/or hepatoprotective drugs.
    Type: Application
    Filed: December 17, 2009
    Publication date: November 10, 2011
    Applicant: TROPHOS
    Inventors: Cyrille Drouot, Abdesslame Nazih, Corinne Chaimbault
  • Complexes for transferring substances of interest into a cell
    Publication number: 20050261214
    Abstract: The present invention concerns new polar compounds, complexes and compositions comprising them, wherein said compound comprises: (i) a polar headgroup spacer, (ii) at least one hydrophobic moiety, and (iii) at least one hydrophilic polymer, and wherein said polar headgroup spacer is coupled to said hydrophobic moiety and to said hydrophilic polymer.
    Type: Application
    Filed: May 14, 2002
    Publication date: November 24, 2005
    Inventors: Serge Braun, Olivier Meyer, Abdesslame Nazih, Denis Heissler
  • Glycerolipid compounds useful for the transfer of an active substance into a target cell
    Patent number: 6743781
    Abstract: The invention concerns novel compounds of formula (I) in which: R1 and R2, which are identical or different, are C6-C23 alkyl or alkenyl radicals, linear or branched or —C(═O)—(C6-C23) alkyl or -c(═O)—(C6-C23) alkenyl, linear or branched. X is the oxygen atom or an amino-NR3 radical, R3 being a hydrogen atom or an inferior alkyl radical of 1 to 4 carbon atoms; n is a positive whole number from 1 to 6; m is a positive whole number from 1 to 6, and when n>1, m can be identical or different. The invention also concerns novel compositions of said compounds and of active substances in particular therapeutically, comprising at least a negative charge for inserting said active susbtances in cells. It concerns in particular novel complexes, of which the active substance consists of one or several nucleic acids, useful for cell transfection.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 1, 2004
    Assignee: Transgene 6.A.
    Inventors: Rainer Bischoff, Denis Heissler, Abdesslame Nazih
  • Lipid compounds and compositions containing them which can be used for the transfer of at least one active substance, in particular a polynucleotide, into a target cell and use in gene therapy
    Publication number: 20020151070
    Abstract: The invention relates to new lipid compounds of formula:
    Type: Application
    Filed: December 19, 2001
    Publication date: October 17, 2002
    Inventors: Rainer Bischoff, Abdesslame Nazih, Yves Cordier
  • Novel lipid complexes for transferring at least one therapeutically active substance, in particular a polynucleotide, into a target cell, and use in gene therapy
    Publication number: 20020025920
    Abstract: The present invention relates to a complex comprising at least a lipid and at least a therapeutically active substance for transferring the therapeutically active substance into a target cell. The present invention also relates to a method of transferring a therapeutically active substance into cells.
    Type: Application
    Filed: September 7, 2001
    Publication date: February 28, 2002
    Inventors: Rainer Bischoff, Denis Heissler, Abdesslame Nazih
  • Lipid compounds and compositions containing same used for the transfer of at least an active substance, in particular a polynucleotide, in a target cell and therapeutic use
    Patent number: 6335199
    Abstract: The present invention relates to lipid compounds of formula I, wherein said compounds are optionally in a cationic form and are optionally combined with one or more biologically acceptable anions. The present invention also relates to complexes comprising at least one cationic lipid compound of the formula I and an active substance comprising negative charges. The present invention further relates to methods of gene therapy using the complexes of the present invention.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: January 1, 2002
    Assignee: Transgene S.A.
    Inventors: Rainer Bischoff, Abdesslame Nazih, Yves Cordier
  • Glycerolipid compounds useful for the transfer of an active substance into a target cell
    Publication number: 20010036927
    Abstract: The invention concerns novel compounds of formula (I) 1
    Type: Application
    Filed: March 2, 2001
    Publication date: November 1, 2001
    Inventors: Rainer Bischoff, Denis Heissler, Abdesslame Nazih
  • Lipid complexes for transferring at least a therapeutically active substance, in particular a polynucleotide into a target cell and use in gene therapy
    Patent number: 6291423
    Abstract: The invention concerns a complex comprising at least a lipid and at least a therapeutically active substance useful for transferring said substance into a target cell, characterised in that said lipid is of formula (I): in which: n1, n2, identical or different are whole numbers between 0 and 1; R1, R2, identical or different are: a) selected among the group consisting of a hydrogen atom and alkyl radicals with 1 to 6 carbon atoms optionally substituted, independently of one another, by a hydroxyl radical; or b) in one particular case for which n1=n2=1, R1 and R2 can form together a divalent alkylene chain of 2 to 3 carbon atoms (C2-C3); R3, R4, identical or different are alkyl radicals of 1 to 6 carbon atoms or can together form a divalent alkylene chain of 2 to 3 carbon atoms (C2-C3); m, p, identical or different are whole numbers between 1 and 10; R5, R6, identical or different are selected in the group consisting of radicals of formula: 1) R7 C(═O)—X— in which: X=NH, O
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: September 18, 2001
    Assignee: Transgene S.A.
    Inventors: Rainer Bischoff, Danis Heissler, Abdesslame Nazih
  • Glycerolipidic compounds used for the transfer of an active substance into a target cell
    Patent number: 6218370
    Abstract: The invention concerns novel of compounds of formula (I) in which: R1 and R2, identical or different are C6-C23 alkyl or alkenyl radicals, linear or branched or —C(═O)-(C6-C23) alkyl or —C(═O)-(C6-C23) alkenyl, linear or branched, X is the oxygen atom or an amino —NR3 radical, R3 being a hydrogen atom or an inferior alkyl radical of 1 to 4 carbon atoms; n is a positive whole number from 1 to 6; m is a positive whole number from 1 to 6, and when n>1, m can be identical or different. The invention also concerns novel compositions of said compounds and of active substances in particular therapeutically, comprising at least a negative charge for inserting said active substances in cells. It concerns in particular novel complexes, of which the active substance consists of one or several nucleic acids, useful for cell transfection.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: April 17, 2001
    Assignee: Transgene S.A.
    Inventors: Rainer Bischoff, Denis Heissler, Abdesslame Nazih